Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs)....
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ftdoajarticles:oai:doaj.org/article:fb49493112cd4e8bbdc1299cda32351d 2023-05-15T15:06:09+02:00 Endogenous phospholipase A2 inhibitors in snakes: a brief overview Patrícia Cota Campos Lutiana Amaral de Melo Gabriel Latorre Fortes Dias Consuelo Latorre Fortes-Dias 2017-01-01T00:00:00Z https://doi.org/10.1186/s40409-016-0092-5 https://doaj.org/article/fb49493112cd4e8bbdc1299cda32351d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-016-0092-5 https://doaj.org/article/fb49493112cd4e8bbdc1299cda32351d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2017) PLA2 inhibitor Phospholipase A2 Snake blood Natural resistance Snakes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2017 ftdoajarticles https://doi.org/10.1186/s40409-016-0092-5 2022-12-31T15:03:21Z Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 22 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
PLA2 inhibitor Phospholipase A2 Snake blood Natural resistance Snakes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
PLA2 inhibitor Phospholipase A2 Snake blood Natural resistance Snakes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Patrícia Cota Campos Lutiana Amaral de Melo Gabriel Latorre Fortes Dias Consuelo Latorre Fortes-Dias Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
topic_facet |
PLA2 inhibitor Phospholipase A2 Snake blood Natural resistance Snakes Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized. |
format |
Article in Journal/Newspaper |
author |
Patrícia Cota Campos Lutiana Amaral de Melo Gabriel Latorre Fortes Dias Consuelo Latorre Fortes-Dias |
author_facet |
Patrícia Cota Campos Lutiana Amaral de Melo Gabriel Latorre Fortes Dias Consuelo Latorre Fortes-Dias |
author_sort |
Patrícia Cota Campos |
title |
Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
title_short |
Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
title_full |
Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
title_fullStr |
Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
title_full_unstemmed |
Endogenous phospholipase A2 inhibitors in snakes: a brief overview |
title_sort |
endogenous phospholipase a2 inhibitors in snakes: a brief overview |
publisher |
SciELO |
publishDate |
2017 |
url |
https://doi.org/10.1186/s40409-016-0092-5 https://doaj.org/article/fb49493112cd4e8bbdc1299cda32351d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2017) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-016-0092-5 https://doaj.org/article/fb49493112cd4e8bbdc1299cda32351d |
op_doi |
https://doi.org/10.1186/s40409-016-0092-5 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
22 |
container_issue |
1 |
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1766337801595387904 |