Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer

• Published in: PeerJ
• Main Authors: Xu Han, Tianyu Liu, Jiabao Zhai, Chang Liu, Wanyu Wang, Chuang Nie, Qi Wang, Xiaojie Zhu, Haibo Zhou, Wenjing Tian
• Format: Article in Journal/Newspaper
• Language: English
• Published: PeerJ Inc. 2022
• Subjects: Gastric cancer; EPHA5 methylation; Peripheral blood leukocytes; Environmental factors; Medicine; R; Biology (General); QH301-705.5; Ora; Orca
• Online Access: https://doi.org/10.7717/peerj.13774; https://doaj.org/article/fb45d9d66b224f48b914eb59a5d61019

Purpose Altered DNA methylation, genetic alterations, and environmental factors are involved in tumorigenesis. As a tumor suppressor gene, abnormal EPHA5 methylation was found in gastric cancer (GC) tissues and was linked to the initiation, progression and prognosis of GC. In this study, the EPHA5 m...