Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh.
There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfun...
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ftdoajarticles:oai:doaj.org/article:fb436f0a5a6c49beb59864ef7213d2b4 2023-05-15T15:12:54+02:00 Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed 2023-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010472 https://doaj.org/article/fb436f0a5a6c49beb59864ef7213d2b4 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010472 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010472 https://doaj.org/article/fb436f0a5a6c49beb59864ef7213d2b4 PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0010472 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010472 2023-02-19T01:28:16Z There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfunction (EED). The purpose of the study was to evaluate the intestinal histological characteristics of stunted children aged between 12-18 months with possible EED. 110 children with chronic malnutrition (52 stunted with length-for-age Z score, LAZ<-2 and 58 at risk of stunting with LAZ <-1 to -2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study protocol who underwent upper gastrointestinal (GI) endoscopy were selected for this study. To explore the association of EED with childhood stunting, upper GI endoscopy was done and the biopsy specimens were studied for histopathology. Villous height and crypt depth were measured and the presence and intensity of inflammatory infiltrates in the lamina propria was investigated. Bivariate analysis was performed to examine the relationship between stunting and histologic morphology. More than 90% children irrespective of nutritional status were diagnosed to have chronic non-specific duodenitis on histopathology. Half of the children from both groups had villous atrophy as well as crypt hyperplasia and lymphocytic infiltration was present in more than 90% children, irrespective of groups. However, no statistically significant difference was observed when compared between the groups. The prevalence of chronic non-specific duodenitis in Bangladeshi children, irrespective of nutritional status, was high. A significant number of these children had abnormal findings in intestinal histomorphology. Trial registration number: ClinicalTrials.gov ID: NCT02812615 Date of first registration: 24/06/2016. https://clinicaltrials.gov/ct2/results?cond=NCT02812615&term=&cntry=&state=&city=&dist. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 1 e0010472 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfunction (EED). The purpose of the study was to evaluate the intestinal histological characteristics of stunted children aged between 12-18 months with possible EED. 110 children with chronic malnutrition (52 stunted with length-for-age Z score, LAZ<-2 and 58 at risk of stunting with LAZ <-1 to -2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study protocol who underwent upper gastrointestinal (GI) endoscopy were selected for this study. To explore the association of EED with childhood stunting, upper GI endoscopy was done and the biopsy specimens were studied for histopathology. Villous height and crypt depth were measured and the presence and intensity of inflammatory infiltrates in the lamina propria was investigated. Bivariate analysis was performed to examine the relationship between stunting and histologic morphology. More than 90% children irrespective of nutritional status were diagnosed to have chronic non-specific duodenitis on histopathology. Half of the children from both groups had villous atrophy as well as crypt hyperplasia and lymphocytic infiltration was present in more than 90% children, irrespective of groups. However, no statistically significant difference was observed when compared between the groups. The prevalence of chronic non-specific duodenitis in Bangladeshi children, irrespective of nutritional status, was high. A significant number of these children had abnormal findings in intestinal histomorphology. Trial registration number: ClinicalTrials.gov ID: NCT02812615 Date of first registration: 24/06/2016. https://clinicaltrials.gov/ct2/results?cond=NCT02812615&term=&cntry=&state=&city=&dist. |
format |
Article in Journal/Newspaper |
author |
Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed |
author_facet |
Md Shabab Hossain S M Khodeza Nahar Begum M Masudur Rahman Mashud Parvez Ramendra Nath Mazumder Shafiqul Alam Sarker Md Mehedi Hasan Shah Mohammad Fahim Md Amran Gazi Subhasish Das Mustafa Mahfuz Tahmeed Ahmed |
author_sort |
Md Shabab Hossain |
title |
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
title_short |
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
title_full |
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
title_fullStr |
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
title_full_unstemmed |
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh. |
title_sort |
environmental enteric dysfunction and small intestinal histomorphology of stunted children in bangladesh. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0010472 https://doaj.org/article/fb436f0a5a6c49beb59864ef7213d2b4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0010472 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010472 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010472 https://doaj.org/article/fb436f0a5a6c49beb59864ef7213d2b4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010472 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
1 |
container_start_page |
e0010472 |
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1766343531426742272 |