Inhibitory effect of deferoxamine on Paracoccidioides brasiliensis survival in human monocytes: reversal by holotransferrin not by apotransferrin Efeito inibidor da deferoxamina sobre a sobrevivência do Paracoccidioides brasiliensis em monócitos humanos: reversão por holotransferrina e não por apotransferrina

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Luciane Alarcão Dias-Melicio, Sueli Aparecida Calvi, Maria Terezinha Serrão Peraçoli, Ângela Maria Victoriano de Campos Soares
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2005
• Subjects: Paracoccidioides brasiliensis; Monocytes; Iron; Deferoxamine; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Droga; Ferro
• Online Access: https://doi.org/10.1590/S0036-46652005000500005; https://doaj.org/article/fae0b5f76654473fbd616b0fa8fddc24

The mechanisms used by Paracoccidioides brasiliensis to survive into phagocytic cells are not clear. Cellular iron metabolism is of critical importance to the growth of several intracellular pathogens whose capacity to multiply in mononuclear phagocytes is dependent on the availability of intracellu...