Insecticide resistance evolution with mixtures and sequences: a model-based explanation
Abstract Background Insecticide resistance threatens effective vector control, especially for mosquitoes and malaria. To manage resistance, recommended insecticide use strategies include mixtures, sequences and rotations. New insecticides are being developed and there is an opportunity to develop us...
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ftdoajarticles:oai:doaj.org/article:fabdd7ddf58d4cefbef0c8c1461b0b9c 2023-05-15T15:16:52+02:00 Insecticide resistance evolution with mixtures and sequences: a model-based explanation Andy South Ian M. Hastings 2018-02-01T00:00:00Z https://doi.org/10.1186/s12936-018-2203-y https://doaj.org/article/fabdd7ddf58d4cefbef0c8c1461b0b9c EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2203-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2203-y 1475-2875 https://doaj.org/article/fabdd7ddf58d4cefbef0c8c1461b0b9c Malaria Journal, Vol 17, Iss 1, Pp 1-20 (2018) Insecticide resistance Public health Mosquitoes Vector-borne diseases Infectious diseases Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2203-y 2022-12-31T10:50:42Z Abstract Background Insecticide resistance threatens effective vector control, especially for mosquitoes and malaria. To manage resistance, recommended insecticide use strategies include mixtures, sequences and rotations. New insecticides are being developed and there is an opportunity to develop use strategies that limit the evolution of further resistance in the short term. A 2013 review of modelling and empirical studies of resistance points to the advantages of mixtures. However, there is limited recent, accessible modelling work addressing the evolution of resistance under different operational strategies. There is an opportunity to improve the level of mechanistic understanding within the operational community of how insecticide resistance can be expected to evolve in response to different strategies. This paper provides a concise, accessible description of a flexible model of the evolution of insecticide resistance. The model is used to develop a mechanistic picture of the evolution of insecticide resistance and how it is likely to respond to potential insecticide use strategies. The aim is to reach an audience unlikely to read a more detailed modelling paper. The model itself, as described here, represents two independent genes coding for resistance to two insecticides. This allows the representation of the use of insecticides in isolation, sequence and mixtures. Results The model is used to demonstrate the evolution of resistance under different scenarios and how this fits with intuitive reasoning about selection pressure. Using an insecticide in a mixture, relative to alone, always prompts slower evolution of resistance to that insecticide. However, when resistance to both insecticides is considered, resistance thresholds may be reached later for a sequence relative to a mixture. Increasing the ability of insecticides to kill susceptible mosquitoes (effectiveness), has the most influence on favouring a mixture over a sequence because one highly effective insecticide provides more protection to another ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Insecticide resistance Public health Mosquitoes Vector-borne diseases Infectious diseases Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Insecticide resistance Public health Mosquitoes Vector-borne diseases Infectious diseases Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Andy South Ian M. Hastings Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
topic_facet |
Insecticide resistance Public health Mosquitoes Vector-borne diseases Infectious diseases Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Insecticide resistance threatens effective vector control, especially for mosquitoes and malaria. To manage resistance, recommended insecticide use strategies include mixtures, sequences and rotations. New insecticides are being developed and there is an opportunity to develop use strategies that limit the evolution of further resistance in the short term. A 2013 review of modelling and empirical studies of resistance points to the advantages of mixtures. However, there is limited recent, accessible modelling work addressing the evolution of resistance under different operational strategies. There is an opportunity to improve the level of mechanistic understanding within the operational community of how insecticide resistance can be expected to evolve in response to different strategies. This paper provides a concise, accessible description of a flexible model of the evolution of insecticide resistance. The model is used to develop a mechanistic picture of the evolution of insecticide resistance and how it is likely to respond to potential insecticide use strategies. The aim is to reach an audience unlikely to read a more detailed modelling paper. The model itself, as described here, represents two independent genes coding for resistance to two insecticides. This allows the representation of the use of insecticides in isolation, sequence and mixtures. Results The model is used to demonstrate the evolution of resistance under different scenarios and how this fits with intuitive reasoning about selection pressure. Using an insecticide in a mixture, relative to alone, always prompts slower evolution of resistance to that insecticide. However, when resistance to both insecticides is considered, resistance thresholds may be reached later for a sequence relative to a mixture. Increasing the ability of insecticides to kill susceptible mosquitoes (effectiveness), has the most influence on favouring a mixture over a sequence because one highly effective insecticide provides more protection to another ... |
format |
Article in Journal/Newspaper |
author |
Andy South Ian M. Hastings |
author_facet |
Andy South Ian M. Hastings |
author_sort |
Andy South |
title |
Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
title_short |
Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
title_full |
Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
title_fullStr |
Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
title_full_unstemmed |
Insecticide resistance evolution with mixtures and sequences: a model-based explanation |
title_sort |
insecticide resistance evolution with mixtures and sequences: a model-based explanation |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2203-y https://doaj.org/article/fabdd7ddf58d4cefbef0c8c1461b0b9c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-20 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2203-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2203-y 1475-2875 https://doaj.org/article/fabdd7ddf58d4cefbef0c8c1461b0b9c |
op_doi |
https://doi.org/10.1186/s12936-018-2203-y |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
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1766347158333685760 |