Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022
Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade...
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ftdoajarticles:oai:doaj.org/article:fa7cff92c75a42d5a8cafbe44f51bfcb 2024-09-09T19:40:09+00:00 Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 Marie Rykkelid Helga Marie Wennberg Elin Richardsen Sveinung Wergeland Sørbye 2024-05-01T00:00:00Z https://doi.org/10.3390/pathogens13050381 https://doaj.org/article/fa7cff92c75a42d5a8cafbe44f51bfcb EN eng MDPI AG https://www.mdpi.com/2076-0817/13/5/381 https://doaj.org/toc/2076-0817 doi:10.3390/pathogens13050381 2076-0817 https://doaj.org/article/fa7cff92c75a42d5a8cafbe44f51bfcb Pathogens, Vol 13, Iss 5, p 381 (2024) human papillomavirus (HPV) HPV vaccine conization LEEP recurrence post-conization recurrence Medicine R article 2024 ftdoajarticles https://doi.org/10.3390/pathogens13050381 2024-08-05T17:49:20Z Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the effect of post-conization HPV vaccination on the viral status of women at six months post-conization, aiming to evaluate the vaccine’s effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing the recurrence of high-grade cellular changes. However, the retrospective design and the insufficient control of confounding variables in this study underscore the need for further studies to confirm these findings. Article in Journal/Newspaper Finnmark Finnmark Troms Directory of Open Access Journals: DOAJ Articles Pathogens 13 5 381 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
human papillomavirus (HPV) HPV vaccine conization LEEP recurrence post-conization recurrence Medicine R |
spellingShingle |
human papillomavirus (HPV) HPV vaccine conization LEEP recurrence post-conization recurrence Medicine R Marie Rykkelid Helga Marie Wennberg Elin Richardsen Sveinung Wergeland Sørbye Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
topic_facet |
human papillomavirus (HPV) HPV vaccine conization LEEP recurrence post-conization recurrence Medicine R |
description |
Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the effect of post-conization HPV vaccination on the viral status of women at six months post-conization, aiming to evaluate the vaccine’s effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing the recurrence of high-grade cellular changes. However, the retrospective design and the insufficient control of confounding variables in this study underscore the need for further studies to confirm these findings. |
format |
Article in Journal/Newspaper |
author |
Marie Rykkelid Helga Marie Wennberg Elin Richardsen Sveinung Wergeland Sørbye |
author_facet |
Marie Rykkelid Helga Marie Wennberg Elin Richardsen Sveinung Wergeland Sørbye |
author_sort |
Marie Rykkelid |
title |
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
title_short |
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
title_full |
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
title_fullStr |
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
title_full_unstemmed |
Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022 |
title_sort |
post-conization hpv vaccination and its impact on viral status: a retrospective cohort study in troms and finnmark, 2022 |
publisher |
MDPI AG |
publishDate |
2024 |
url |
https://doi.org/10.3390/pathogens13050381 https://doaj.org/article/fa7cff92c75a42d5a8cafbe44f51bfcb |
genre |
Finnmark Finnmark Troms |
genre_facet |
Finnmark Finnmark Troms |
op_source |
Pathogens, Vol 13, Iss 5, p 381 (2024) |
op_relation |
https://www.mdpi.com/2076-0817/13/5/381 https://doaj.org/toc/2076-0817 doi:10.3390/pathogens13050381 2076-0817 https://doaj.org/article/fa7cff92c75a42d5a8cafbe44f51bfcb |
op_doi |
https://doi.org/10.3390/pathogens13050381 |
container_title |
Pathogens |
container_volume |
13 |
container_issue |
5 |
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381 |
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1809909466164887552 |