Mayaro fever: A brief review on the immune profile
Mayaro virus is an emergent alphavirus that infects humans, leading to Mayaro fever. Approximately fifty percent of infected patients develop arthritis symptoms in the recovery phase, a phase that can last up to a year. The literature about Mayaro virus infection and its immune response is scarce, w...
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Wolters Kluwer Medknow Publications
2020
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ftdoajarticles:oai:doaj.org/article:fa6f70e8899d4fb68f649d48c4db79f3 2023-05-15T15:07:04+02:00 Mayaro fever: A brief review on the immune profile Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo José Luiz de Lima Filho 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.276315 https://doaj.org/article/fa6f70e8899d4fb68f649d48c4db79f3 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=3;spage=95;epage=100;aulast=Ferreira https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.276315 https://doaj.org/article/fa6f70e8899d4fb68f649d48c4db79f3 Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 3, Pp 95-100 (2020) emergent virus mayaro virus cytokines chemokine molecular characterization Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.276315 2022-12-31T06:15:14Z Mayaro virus is an emergent alphavirus that infects humans, leading to Mayaro fever. Approximately fifty percent of infected patients develop arthritis symptoms in the recovery phase, a phase that can last up to a year. The literature about Mayaro virus infection and its immune response is scarce, which may hamper the development of treatment strategies. We summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients, and relate this molecular characterization with the immune response. VEGF and IL-12/p70 show pronounced changes in patients in the acute phase, suggesting the development of cellular immunity and Th1 response. IL-6, IL-7, CXCL8/IL-8, IL-13, IL-17, and IFN-γ are elevated in patients with arthritis symptoms in the long-term recovery phase, which may be related to the continuous inflammatory process, a possible Th2 inhibiting and promoting Th17 process. Although few studies discuss the issue, with a small number of patients and different backgrounds, inflammatory and immune response and manifestations seem to be closely linked. This information may help to develop the appropriate treatment strategies in Mayaro virus infection. Therefore, we analyzed and summarized data available in literature. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 3 95 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
emergent virus mayaro virus cytokines chemokine molecular characterization Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
emergent virus mayaro virus cytokines chemokine molecular characterization Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo José Luiz de Lima Filho Mayaro fever: A brief review on the immune profile |
topic_facet |
emergent virus mayaro virus cytokines chemokine molecular characterization Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Mayaro virus is an emergent alphavirus that infects humans, leading to Mayaro fever. Approximately fifty percent of infected patients develop arthritis symptoms in the recovery phase, a phase that can last up to a year. The literature about Mayaro virus infection and its immune response is scarce, which may hamper the development of treatment strategies. We summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients, and relate this molecular characterization with the immune response. VEGF and IL-12/p70 show pronounced changes in patients in the acute phase, suggesting the development of cellular immunity and Th1 response. IL-6, IL-7, CXCL8/IL-8, IL-13, IL-17, and IFN-γ are elevated in patients with arthritis symptoms in the long-term recovery phase, which may be related to the continuous inflammatory process, a possible Th2 inhibiting and promoting Th17 process. Although few studies discuss the issue, with a small number of patients and different backgrounds, inflammatory and immune response and manifestations seem to be closely linked. This information may help to develop the appropriate treatment strategies in Mayaro virus infection. Therefore, we analyzed and summarized data available in literature. |
format |
Article in Journal/Newspaper |
author |
Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo José Luiz de Lima Filho |
author_facet |
Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo José Luiz de Lima Filho |
author_sort |
Jean Moisés Ferreira |
title |
Mayaro fever: A brief review on the immune profile |
title_short |
Mayaro fever: A brief review on the immune profile |
title_full |
Mayaro fever: A brief review on the immune profile |
title_fullStr |
Mayaro fever: A brief review on the immune profile |
title_full_unstemmed |
Mayaro fever: A brief review on the immune profile |
title_sort |
mayaro fever: a brief review on the immune profile |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.276315 https://doaj.org/article/fa6f70e8899d4fb68f649d48c4db79f3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 3, Pp 95-100 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=3;spage=95;epage=100;aulast=Ferreira https://doaj.org/toc/2588-9222 2588-9222 doi:10.4103/2221-1691.276315 https://doaj.org/article/fa6f70e8899d4fb68f649d48c4db79f3 |
op_doi |
https://doi.org/10.4103/2221-1691.276315 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
3 |
container_start_page |
95 |
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