The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

• Published in: Malaria Journal
• Main Authors: Arnot David E, Hviid Lars, Hassenkam Tue, Theander Thor G, Barfod Lea, Dobrilovic Tina, Salanti Ali, Joergensen Lars M
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2010
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; The Knob
• Online Access: https://doi.org/10.1186/1475-2875-9-100; https://doaj.org/article/fa2caf75ff17449c91710622e1cf15dc

Abstract Background Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-receptor binding reaction or how the topology of PfEMP1 on the paras...