Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations.
The wMel infection of Drosophila melanogaster was successfully transferred into Aedes aegypti mosquitoes where it has the potential to suppress dengue and other arboviruses. The infection was subsequently spread into two natural populations at Yorkeys Knob and Gordonvale near Cairns, Queensland in 2...
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ftdoajarticles:oai:doaj.org/article:fa204b6b5c9e4b999a28ccd0ed1920fc 2023-05-15T15:07:33+02:00 Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. Ary A Hoffmann Inaki Iturbe-Ormaetxe Ashley G Callahan Ben L Phillips Katrina Billington Jason K Axford Brian Montgomery Andrew P Turley Scott L O'Neill 2014-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003115 https://doaj.org/article/fa204b6b5c9e4b999a28ccd0ed1920fc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4161343?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003115 https://doaj.org/article/fa204b6b5c9e4b999a28ccd0ed1920fc PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3115 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003115 2022-12-31T00:11:29Z The wMel infection of Drosophila melanogaster was successfully transferred into Aedes aegypti mosquitoes where it has the potential to suppress dengue and other arboviruses. The infection was subsequently spread into two natural populations at Yorkeys Knob and Gordonvale near Cairns, Queensland in 2011. Here we report on the stability of the infection following introduction and we characterize factors influencing the ongoing dynamics of the infection in these two populations. While the Wolbachia infection always remained high and near fixation in both locations, there was a persistent low frequency of uninfected mosquitoes. These uninfected mosquitoes showed weak spatial structure at both release sites although there was some clustering around two areas in Gordonvale. Infected females from both locations showed perfect maternal transmission consistent with patterns previously established pre-release in laboratory tests. After >2 years under field conditions, the infection continued to show complete cytoplasmic incompatibility across multiple gonotrophic cycles but persistent deleterious fitness effects, suggesting that host effects were stable over time. These results point to the stability of Wolbachia infections and their impact on hosts following local invasion, and also highlight the continued persistence of uninfected individuals at a low frequency most likely due to immigration. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Queensland PLoS Neglected Tropical Diseases 8 9 e3115 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ary A Hoffmann Inaki Iturbe-Ormaetxe Ashley G Callahan Ben L Phillips Katrina Billington Jason K Axford Brian Montgomery Andrew P Turley Scott L O'Neill Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The wMel infection of Drosophila melanogaster was successfully transferred into Aedes aegypti mosquitoes where it has the potential to suppress dengue and other arboviruses. The infection was subsequently spread into two natural populations at Yorkeys Knob and Gordonvale near Cairns, Queensland in 2011. Here we report on the stability of the infection following introduction and we characterize factors influencing the ongoing dynamics of the infection in these two populations. While the Wolbachia infection always remained high and near fixation in both locations, there was a persistent low frequency of uninfected mosquitoes. These uninfected mosquitoes showed weak spatial structure at both release sites although there was some clustering around two areas in Gordonvale. Infected females from both locations showed perfect maternal transmission consistent with patterns previously established pre-release in laboratory tests. After >2 years under field conditions, the infection continued to show complete cytoplasmic incompatibility across multiple gonotrophic cycles but persistent deleterious fitness effects, suggesting that host effects were stable over time. These results point to the stability of Wolbachia infections and their impact on hosts following local invasion, and also highlight the continued persistence of uninfected individuals at a low frequency most likely due to immigration. |
format |
Article in Journal/Newspaper |
author |
Ary A Hoffmann Inaki Iturbe-Ormaetxe Ashley G Callahan Ben L Phillips Katrina Billington Jason K Axford Brian Montgomery Andrew P Turley Scott L O'Neill |
author_facet |
Ary A Hoffmann Inaki Iturbe-Ormaetxe Ashley G Callahan Ben L Phillips Katrina Billington Jason K Axford Brian Montgomery Andrew P Turley Scott L O'Neill |
author_sort |
Ary A Hoffmann |
title |
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
title_short |
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
title_full |
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
title_fullStr |
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
title_full_unstemmed |
Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. |
title_sort |
stability of the wmel wolbachia infection following invasion into aedes aegypti populations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003115 https://doaj.org/article/fa204b6b5c9e4b999a28ccd0ed1920fc |
geographic |
Arctic Queensland |
geographic_facet |
Arctic Queensland |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3115 (2014) |
op_relation |
http://europepmc.org/articles/PMC4161343?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003115 https://doaj.org/article/fa204b6b5c9e4b999a28ccd0ed1920fc |
op_doi |
https://doi.org/10.1371/journal.pntd.0003115 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
9 |
container_start_page |
e3115 |
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1766339027238125568 |