Contributions of natural killer cells to the immune response against Plasmodium
Abstract Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as P...
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ftdoajarticles:oai:doaj.org/article:f981c507d01b473a97cd0781212768c7 2023-05-15T15:10:33+02:00 Contributions of natural killer cells to the immune response against Plasmodium Kristina S. Burrack Geoffrey T. Hart Sara E. Hamilton 2019-09-01T00:00:00Z https://doi.org/10.1186/s12936-019-2953-1 https://doaj.org/article/f981c507d01b473a97cd0781212768c7 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2953-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2953-1 1475-2875 https://doaj.org/article/f981c507d01b473a97cd0781212768c7 Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) Malaria NK cells Cytotoxicity Cytokines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2953-1 2022-12-31T09:51:47Z Abstract Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection—prior to the activation and expansion of antigen-specific T cells—through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γ chain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria NK cells Cytotoxicity Cytokines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria NK cells Cytotoxicity Cytokines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kristina S. Burrack Geoffrey T. Hart Sara E. Hamilton Contributions of natural killer cells to the immune response against Plasmodium |
topic_facet |
Malaria NK cells Cytotoxicity Cytokines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection—prior to the activation and expansion of antigen-specific T cells—through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γ chain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens. |
format |
Article in Journal/Newspaper |
author |
Kristina S. Burrack Geoffrey T. Hart Sara E. Hamilton |
author_facet |
Kristina S. Burrack Geoffrey T. Hart Sara E. Hamilton |
author_sort |
Kristina S. Burrack |
title |
Contributions of natural killer cells to the immune response against Plasmodium |
title_short |
Contributions of natural killer cells to the immune response against Plasmodium |
title_full |
Contributions of natural killer cells to the immune response against Plasmodium |
title_fullStr |
Contributions of natural killer cells to the immune response against Plasmodium |
title_full_unstemmed |
Contributions of natural killer cells to the immune response against Plasmodium |
title_sort |
contributions of natural killer cells to the immune response against plasmodium |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2953-1 https://doaj.org/article/f981c507d01b473a97cd0781212768c7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2953-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2953-1 1475-2875 https://doaj.org/article/f981c507d01b473a97cd0781212768c7 |
op_doi |
https://doi.org/10.1186/s12936-019-2953-1 |
container_title |
Malaria Journal |
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18 |
container_issue |
1 |
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1766341562961231872 |