Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea
Abstract Background The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malari...
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ftdoajarticles:oai:doaj.org/article:f95be2091b9e4d548e2bb1e44e471737 2023-05-15T15:12:20+02:00 Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea Lee Wonja Mita Toshihiro Palacpac Nirianne MQ Kim Jung-Yeon Honma Hajime Horii Toshihiro Tanabe Kazuyuki 2011-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-257 https://doaj.org/article/f95be2091b9e4d548e2bb1e44e471737 EN eng BMC http://www.malariajournal.com/content/10/1/257 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-257 1475-2875 https://doaj.org/article/f95be2091b9e4d548e2bb1e44e471737 Malaria Journal, Vol 10, Iss 1, p 257 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-257 2022-12-31T08:11:51Z Abstract Background The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is generally low genetic diversity with very few strains involved. In this study, the genetic diversity and population structure of P. vivax in South Korea were explored by analysing microsatellite polymorphism. Methods Sequences for 13 microsatellite loci distributed across the twelve chromosomes of P. vivax were obtained from 58 South Korean isolates collected during two sampling periods, namely 1997-2000 and 2007. The sequences were used for the analysis of expected heterozygosity and multilocus genotype diversity. Population structure was evaluated using STRUCTURE version 2.3.2. Linkage disequilibrium was also analysed to investigate the extent of outbreeding in the P. vivax population. Results Mean expected heterozygosity significantly increased from 0.382 in 1997-2000 to 0.545 in 2007 ( P < 0.05). The number of multilocus genotypes was 7 and 27; and genotype diversity was statistically significant ( P < 0.01) at 0.661 and 0.995 in 1997-2000 and 2007, respectively. Analysis by STRUCTURE showed a more complex population structure in 2007 than in 1997-2000. Linkage disequilibrium between 13 microsatellites, although significant in both time points, was notably lower in 2007. Conclusions The present microsatellite analysis clearly showed recent increase of genetic diversity and recent relaxation of the strong population structure observed in 1997-2000. These results suggest that multiple genotypes not present previously recently migrated into South Korea, accompanied by substantial outbreeding between different genotypes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 257 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Lee Wonja Mita Toshihiro Palacpac Nirianne MQ Kim Jung-Yeon Honma Hajime Horii Toshihiro Tanabe Kazuyuki Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is generally low genetic diversity with very few strains involved. In this study, the genetic diversity and population structure of P. vivax in South Korea were explored by analysing microsatellite polymorphism. Methods Sequences for 13 microsatellite loci distributed across the twelve chromosomes of P. vivax were obtained from 58 South Korean isolates collected during two sampling periods, namely 1997-2000 and 2007. The sequences were used for the analysis of expected heterozygosity and multilocus genotype diversity. Population structure was evaluated using STRUCTURE version 2.3.2. Linkage disequilibrium was also analysed to investigate the extent of outbreeding in the P. vivax population. Results Mean expected heterozygosity significantly increased from 0.382 in 1997-2000 to 0.545 in 2007 ( P < 0.05). The number of multilocus genotypes was 7 and 27; and genotype diversity was statistically significant ( P < 0.01) at 0.661 and 0.995 in 1997-2000 and 2007, respectively. Analysis by STRUCTURE showed a more complex population structure in 2007 than in 1997-2000. Linkage disequilibrium between 13 microsatellites, although significant in both time points, was notably lower in 2007. Conclusions The present microsatellite analysis clearly showed recent increase of genetic diversity and recent relaxation of the strong population structure observed in 1997-2000. These results suggest that multiple genotypes not present previously recently migrated into South Korea, accompanied by substantial outbreeding between different genotypes. |
format |
Article in Journal/Newspaper |
author |
Lee Wonja Mita Toshihiro Palacpac Nirianne MQ Kim Jung-Yeon Honma Hajime Horii Toshihiro Tanabe Kazuyuki |
author_facet |
Lee Wonja Mita Toshihiro Palacpac Nirianne MQ Kim Jung-Yeon Honma Hajime Horii Toshihiro Tanabe Kazuyuki |
author_sort |
Lee Wonja |
title |
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
title_short |
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
title_full |
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
title_fullStr |
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
title_full_unstemmed |
Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea |
title_sort |
recent increase of genetic diversity in plasmodium vivax population in the republic of korea |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-257 https://doaj.org/article/f95be2091b9e4d548e2bb1e44e471737 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 257 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/257 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-257 1475-2875 https://doaj.org/article/f95be2091b9e4d548e2bb1e44e471737 |
op_doi |
https://doi.org/10.1186/1475-2875-10-257 |
container_title |
Malaria Journal |
container_volume |
10 |
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1 |
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257 |
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1766343035742846976 |