Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail
Abstract Background In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient c...
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ftdoajarticles:oai:doaj.org/article:f950aae45a1d44b7a01cb1bd93e3184e 2023-05-15T17:43:35+02:00 Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail Halvorsen Dag S Viitanen Matti Straume Bjørn Engstad Torgeir A Andersen Fred Hykkerud Samuel Sjøbrend Kjell 2010-04-01T00:00:00Z https://doi.org/10.1186/1471-2288-10-35 https://doaj.org/article/f950aae45a1d44b7a01cb1bd93e3184e EN eng BMC http://www.biomedcentral.com/1471-2288/10/35 https://doaj.org/toc/1471-2288 doi:10.1186/1471-2288-10-35 1471-2288 https://doaj.org/article/f950aae45a1d44b7a01cb1bd93e3184e BMC Medical Research Methodology, Vol 10, Iss 1, p 35 (2010) Medicine (General) R5-920 article 2010 ftdoajarticles https://doi.org/10.1186/1471-2288-10-35 2022-12-31T09:10:27Z Abstract Background In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient characteristics differ between study samples recruited from general practice and from a population based screening by mail within the same geographic areas in rural Northern Norway. Methods An interventional study in nine municipalities with 70000 inhabitants was designed. Patients were recruited from general practice or by population based screening of cognitive function by mail. We sent a questionnaire to 11807 individuals ≥ 65 years of age of whom 3767 responded. Among these, 438 individuals whose answers raised a suspicion of cognitive impairment were invited to an extended cognitive and clinical examination. Descriptive statistics, chi-square, independent sample t-test and analyses of covariance adjusted for possible confounders were used. Results The final study samples included 100 patients recruited by screening and 87 from general practice. Screening through mail recruited younger and more self-reliant male patients with a higher MMSE sum score, whereas older women with more severe cognitive impairment were recruited from general practice. Adjustment for age did not alter the statistically significant differences of cognitive function, self-reliance and gender distribution between patients recruited by screening and from general practice. Conclusions Different recruitment procedures of individuals with cognitive impairment provided study samples with different demographic characteristics. Initial cognitive screening by mail, preceding extended cognitive testing and clinical examination may be a suitable recruitment strategy in studies of early stage AD. Clinical Registration ClinicalTrial.gov Identifier: NCT00443014 Article in Journal/Newspaper Northern Norway Directory of Open Access Journals: DOAJ Articles Norway BMC Medical Research Methodology 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Halvorsen Dag S Viitanen Matti Straume Bjørn Engstad Torgeir A Andersen Fred Hykkerud Samuel Sjøbrend Kjell Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
topic_facet |
Medicine (General) R5-920 |
description |
Abstract Background In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient characteristics differ between study samples recruited from general practice and from a population based screening by mail within the same geographic areas in rural Northern Norway. Methods An interventional study in nine municipalities with 70000 inhabitants was designed. Patients were recruited from general practice or by population based screening of cognitive function by mail. We sent a questionnaire to 11807 individuals ≥ 65 years of age of whom 3767 responded. Among these, 438 individuals whose answers raised a suspicion of cognitive impairment were invited to an extended cognitive and clinical examination. Descriptive statistics, chi-square, independent sample t-test and analyses of covariance adjusted for possible confounders were used. Results The final study samples included 100 patients recruited by screening and 87 from general practice. Screening through mail recruited younger and more self-reliant male patients with a higher MMSE sum score, whereas older women with more severe cognitive impairment were recruited from general practice. Adjustment for age did not alter the statistically significant differences of cognitive function, self-reliance and gender distribution between patients recruited by screening and from general practice. Conclusions Different recruitment procedures of individuals with cognitive impairment provided study samples with different demographic characteristics. Initial cognitive screening by mail, preceding extended cognitive testing and clinical examination may be a suitable recruitment strategy in studies of early stage AD. Clinical Registration ClinicalTrial.gov Identifier: NCT00443014 |
format |
Article in Journal/Newspaper |
author |
Halvorsen Dag S Viitanen Matti Straume Bjørn Engstad Torgeir A Andersen Fred Hykkerud Samuel Sjøbrend Kjell |
author_facet |
Halvorsen Dag S Viitanen Matti Straume Bjørn Engstad Torgeir A Andersen Fred Hykkerud Samuel Sjøbrend Kjell |
author_sort |
Halvorsen Dag S |
title |
Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
title_short |
Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
title_full |
Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
title_fullStr |
Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
title_full_unstemmed |
Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail |
title_sort |
recruitment methods in alzheimer's disease research: general practice versus population based screening by mail |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1471-2288-10-35 https://doaj.org/article/f950aae45a1d44b7a01cb1bd93e3184e |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
BMC Medical Research Methodology, Vol 10, Iss 1, p 35 (2010) |
op_relation |
http://www.biomedcentral.com/1471-2288/10/35 https://doaj.org/toc/1471-2288 doi:10.1186/1471-2288-10-35 1471-2288 https://doaj.org/article/f950aae45a1d44b7a01cb1bd93e3184e |
op_doi |
https://doi.org/10.1186/1471-2288-10-35 |
container_title |
BMC Medical Research Methodology |
container_volume |
10 |
container_issue |
1 |
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1766145692664856576 |