Reassessing therapeutic antibodies for neglected and tropical diseases.
In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of these new medicines has been driven primarily by new approaches in inflammatory diseases and oncology, especially in immuno-o...
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ftdoajarticles:oai:doaj.org/article:f943fdcc8ea44d97886eddaabf3dcef9 2023-05-15T15:05:43+02:00 Reassessing therapeutic antibodies for neglected and tropical diseases. Rob Hooft van Huijsduijnen Somei Kojima Dee Carter Hisafumi Okabe Akihide Sato Wataru Akahata Timothy N C Wells Kei Katsuno 2020-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007860 https://doaj.org/article/f943fdcc8ea44d97886eddaabf3dcef9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007860 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007860 https://doaj.org/article/f943fdcc8ea44d97886eddaabf3dcef9 PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007860 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007860 2022-12-31T13:53:10Z In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of these new medicines has been driven primarily by new approaches in inflammatory diseases and oncology, especially in immuno-oncology. Other recent successes have included new antibodies for use in viral diseases, including HIV. The perception of very high costs associated with mAbs has led to the assumption that they play no role in prophylaxis for diseases of poverty. However, improvements in antibody-expression yields and manufacturing processes indicate this is a cost-effective option for providing protection from many types of infection that should be revisited. Recent technology developments also indicate that several months of protection could be achieved with a single dose. Moreover, new methods in B cell sorting now enable the systematic identification of high-quality antibodies from humanized mice, or patients. This Review discusses the potential for passive immunization against schistosomiasis, fungal infections, dengue, and other neglected diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 1 e0007860 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rob Hooft van Huijsduijnen Somei Kojima Dee Carter Hisafumi Okabe Akihide Sato Wataru Akahata Timothy N C Wells Kei Katsuno Reassessing therapeutic antibodies for neglected and tropical diseases. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators. The discovery of these new medicines has been driven primarily by new approaches in inflammatory diseases and oncology, especially in immuno-oncology. Other recent successes have included new antibodies for use in viral diseases, including HIV. The perception of very high costs associated with mAbs has led to the assumption that they play no role in prophylaxis for diseases of poverty. However, improvements in antibody-expression yields and manufacturing processes indicate this is a cost-effective option for providing protection from many types of infection that should be revisited. Recent technology developments also indicate that several months of protection could be achieved with a single dose. Moreover, new methods in B cell sorting now enable the systematic identification of high-quality antibodies from humanized mice, or patients. This Review discusses the potential for passive immunization against schistosomiasis, fungal infections, dengue, and other neglected diseases. |
format |
Article in Journal/Newspaper |
author |
Rob Hooft van Huijsduijnen Somei Kojima Dee Carter Hisafumi Okabe Akihide Sato Wataru Akahata Timothy N C Wells Kei Katsuno |
author_facet |
Rob Hooft van Huijsduijnen Somei Kojima Dee Carter Hisafumi Okabe Akihide Sato Wataru Akahata Timothy N C Wells Kei Katsuno |
author_sort |
Rob Hooft van Huijsduijnen |
title |
Reassessing therapeutic antibodies for neglected and tropical diseases. |
title_short |
Reassessing therapeutic antibodies for neglected and tropical diseases. |
title_full |
Reassessing therapeutic antibodies for neglected and tropical diseases. |
title_fullStr |
Reassessing therapeutic antibodies for neglected and tropical diseases. |
title_full_unstemmed |
Reassessing therapeutic antibodies for neglected and tropical diseases. |
title_sort |
reassessing therapeutic antibodies for neglected and tropical diseases. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0007860 https://doaj.org/article/f943fdcc8ea44d97886eddaabf3dcef9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007860 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007860 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007860 https://doaj.org/article/f943fdcc8ea44d97886eddaabf3dcef9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007860 |
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PLOS Neglected Tropical Diseases |
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14 |
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1 |
container_start_page |
e0007860 |
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