Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding
Arctic charr (Salvelinus alpinus) is a high-value species for the Nordic aquaculture. The highly variable reproductive performance that is commonly observed in commercial farms is hindering the expansion of the Arctic charr industry in Sweden. Traits related to sperm motility (total motility; curvil...
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ftdoajarticles:oai:doaj.org/article:f8f2dfdcf4144076a807ed3ac920ee63 2023-05-15T14:29:58+02:00 Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding Khrystyna Kurta Henrik Jeuthe Dirk Jan de Koning Christos Palaiokostas 2022-08-01T00:00:00Z https://doi.org/10.1016/j.aqrep.2022.101234 https://doaj.org/article/f8f2dfdcf4144076a807ed3ac920ee63 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2352513422002307 https://doaj.org/toc/2352-5134 2352-5134 doi:10.1016/j.aqrep.2022.101234 https://doaj.org/article/f8f2dfdcf4144076a807ed3ac920ee63 Aquaculture Reports, Vol 25, Iss , Pp 101234- (2022) Arctic charr (Salvelinus alpinus) Sperm quality Motility Genetic parameters GWAS DdRAD Aquaculture. Fisheries. Angling SH1-691 article 2022 ftdoajarticles https://doi.org/10.1016/j.aqrep.2022.101234 2022-12-31T00:46:17Z Arctic charr (Salvelinus alpinus) is a high-value species for the Nordic aquaculture. The highly variable reproductive performance that is commonly observed in commercial farms is hindering the expansion of the Arctic charr industry in Sweden. Traits related to sperm motility (total motility; curvilinear velocity; average path velocity; straight-line velocity) and concentration can play a pivotal role in male fertility. Selective breeding practices could offer solutions and contribute to improving male fertility. The current study aimed to investigate the magnitude of genetic variance for sperm quality traits in a selectively bred population of Arctic charr from Sweden and evaluate the possibility of their improvement through selection. Sperm motility and concentration were recorded using a computer-assisted semen analysis (CASA) system and a NucleoCounter, respectively, in over 400 males from year-class 2017. Double digest restriction-site associated DNA sequencing (ddRAD-seq) was applied in a subset of the recorded animals (n = 329), resulting in the detection of over 5000 single nucleotide polymorphisms (SNPs). Moderate heritability estimates were obtained for the recorded semen traits using both pedigree (0.21–0.32; SE 0.09) and genomic (0.23–0.26; SE 0.09) relationship matrices. A genome-wide association study (GWAS) detected a single SNP significantly associated (P < 1e-05) with total sperm motility on chromosome LG7 in relatively close proximity (500 Kb) to PTPN11 a gene previously associated with sperm quality traits in mammals. Moreover, weighted single-step genomic best linear unbiased prediction (WssGBLUP) pinpointed genomic regions explaining more than 3 % of the additive genetic variance for both the motility traits and the sperm concentration. Finally, the efficiency of genomic prediction was tested using a 3-fold cross-validation scheme. Higher prediction accuracy for total motility and velocities (both curvilinear and average path) was obtained using genomic information (0.26–0.29, SE ... Article in Journal/Newspaper Arctic charr Arctic Salvelinus alpinus Directory of Open Access Journals: DOAJ Articles Arctic Aquaculture Reports 25 101234 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic charr (Salvelinus alpinus) Sperm quality Motility Genetic parameters GWAS DdRAD Aquaculture. Fisheries. Angling SH1-691 |
spellingShingle |
Arctic charr (Salvelinus alpinus) Sperm quality Motility Genetic parameters GWAS DdRAD Aquaculture. Fisheries. Angling SH1-691 Khrystyna Kurta Henrik Jeuthe Dirk Jan de Koning Christos Palaiokostas Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
topic_facet |
Arctic charr (Salvelinus alpinus) Sperm quality Motility Genetic parameters GWAS DdRAD Aquaculture. Fisheries. Angling SH1-691 |
description |
Arctic charr (Salvelinus alpinus) is a high-value species for the Nordic aquaculture. The highly variable reproductive performance that is commonly observed in commercial farms is hindering the expansion of the Arctic charr industry in Sweden. Traits related to sperm motility (total motility; curvilinear velocity; average path velocity; straight-line velocity) and concentration can play a pivotal role in male fertility. Selective breeding practices could offer solutions and contribute to improving male fertility. The current study aimed to investigate the magnitude of genetic variance for sperm quality traits in a selectively bred population of Arctic charr from Sweden and evaluate the possibility of their improvement through selection. Sperm motility and concentration were recorded using a computer-assisted semen analysis (CASA) system and a NucleoCounter, respectively, in over 400 males from year-class 2017. Double digest restriction-site associated DNA sequencing (ddRAD-seq) was applied in a subset of the recorded animals (n = 329), resulting in the detection of over 5000 single nucleotide polymorphisms (SNPs). Moderate heritability estimates were obtained for the recorded semen traits using both pedigree (0.21–0.32; SE 0.09) and genomic (0.23–0.26; SE 0.09) relationship matrices. A genome-wide association study (GWAS) detected a single SNP significantly associated (P < 1e-05) with total sperm motility on chromosome LG7 in relatively close proximity (500 Kb) to PTPN11 a gene previously associated with sperm quality traits in mammals. Moreover, weighted single-step genomic best linear unbiased prediction (WssGBLUP) pinpointed genomic regions explaining more than 3 % of the additive genetic variance for both the motility traits and the sperm concentration. Finally, the efficiency of genomic prediction was tested using a 3-fold cross-validation scheme. Higher prediction accuracy for total motility and velocities (both curvilinear and average path) was obtained using genomic information (0.26–0.29, SE ... |
format |
Article in Journal/Newspaper |
author |
Khrystyna Kurta Henrik Jeuthe Dirk Jan de Koning Christos Palaiokostas |
author_facet |
Khrystyna Kurta Henrik Jeuthe Dirk Jan de Koning Christos Palaiokostas |
author_sort |
Khrystyna Kurta |
title |
Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
title_short |
Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
title_full |
Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
title_fullStr |
Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
title_full_unstemmed |
Evaluating the potential of improving sperm quality traits in farmed Arctic charr (Salvelinus alpinus) using selective breeding |
title_sort |
evaluating the potential of improving sperm quality traits in farmed arctic charr (salvelinus alpinus) using selective breeding |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://doi.org/10.1016/j.aqrep.2022.101234 https://doaj.org/article/f8f2dfdcf4144076a807ed3ac920ee63 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic charr Arctic Salvelinus alpinus |
genre_facet |
Arctic charr Arctic Salvelinus alpinus |
op_source |
Aquaculture Reports, Vol 25, Iss , Pp 101234- (2022) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2352513422002307 https://doaj.org/toc/2352-5134 2352-5134 doi:10.1016/j.aqrep.2022.101234 https://doaj.org/article/f8f2dfdcf4144076a807ed3ac920ee63 |
op_doi |
https://doi.org/10.1016/j.aqrep.2022.101234 |
container_title |
Aquaculture Reports |
container_volume |
25 |
container_start_page |
101234 |
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1766303913147891712 |