New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment
Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimoni...
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ftdoajarticles:oai:doaj.org/article:f8d70aeae8864101872ee0d579e634db 2023-05-15T15:06:06+02:00 New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment Miguel Angel Chávez-Fumagalli Tatiana Gomes Ribeiro Rachel Oliveira Castilho Simone Odília Antunes Fernandes Valbert Nascimento Cardoso Cecília Steinberg Perilo Coelho Débora Vasconcelos Costa Mendonça Manuel Soto Carlos Alberto Pereira Tavares André Augusto Gomes Faraco Eduardo Antonio Ferraz Coelho 2015-06-01T00:00:00Z https://doi.org/10.1590/0037-8682-0138-2015 https://doaj.org/article/f8d70aeae8864101872ee0d579e634db EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000300235&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0138-2015 https://doaj.org/article/f8d70aeae8864101872ee0d579e634db Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 3, Pp 235-242 (2015) Amphotericin B Leishmaniasis Nanoparticles Toxicity Treatment Lipid-based formulations Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0138-2015 2022-12-31T02:52:53Z Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimonials have been the drugs of choice to treat the disease for more than six decades; however, they exhibit high toxicity and are not indicated for children, for pregnant or breastfeeding women or for chronically ill patients. Amphotericin B (AmpB) is a second-line drug, and although it has been increasingly used to treat visceral leishmaniasis (VL), its clinical use has been hampered due to its high toxicity. This review focuses on the development and in vivo usage of new delivery systems for AmpB that aim to decrease its toxicity without altering its therapeutic efficacy. These new formulations, when adjusted with regard to their production costs, may be considered new drug delivery systems that promise to improve the treatment of leishmaniasis, by reducing the side effects and the number of doses while permitting a satisfactory cost-benefit ratio. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 3 235 242 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Amphotericin B Leishmaniasis Nanoparticles Toxicity Treatment Lipid-based formulations Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Amphotericin B Leishmaniasis Nanoparticles Toxicity Treatment Lipid-based formulations Arctic medicine. Tropical medicine RC955-962 Miguel Angel Chávez-Fumagalli Tatiana Gomes Ribeiro Rachel Oliveira Castilho Simone Odília Antunes Fernandes Valbert Nascimento Cardoso Cecília Steinberg Perilo Coelho Débora Vasconcelos Costa Mendonça Manuel Soto Carlos Alberto Pereira Tavares André Augusto Gomes Faraco Eduardo Antonio Ferraz Coelho New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
topic_facet |
Amphotericin B Leishmaniasis Nanoparticles Toxicity Treatment Lipid-based formulations Arctic medicine. Tropical medicine RC955-962 |
description |
Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimonials have been the drugs of choice to treat the disease for more than six decades; however, they exhibit high toxicity and are not indicated for children, for pregnant or breastfeeding women or for chronically ill patients. Amphotericin B (AmpB) is a second-line drug, and although it has been increasingly used to treat visceral leishmaniasis (VL), its clinical use has been hampered due to its high toxicity. This review focuses on the development and in vivo usage of new delivery systems for AmpB that aim to decrease its toxicity without altering its therapeutic efficacy. These new formulations, when adjusted with regard to their production costs, may be considered new drug delivery systems that promise to improve the treatment of leishmaniasis, by reducing the side effects and the number of doses while permitting a satisfactory cost-benefit ratio. |
format |
Article in Journal/Newspaper |
author |
Miguel Angel Chávez-Fumagalli Tatiana Gomes Ribeiro Rachel Oliveira Castilho Simone Odília Antunes Fernandes Valbert Nascimento Cardoso Cecília Steinberg Perilo Coelho Débora Vasconcelos Costa Mendonça Manuel Soto Carlos Alberto Pereira Tavares André Augusto Gomes Faraco Eduardo Antonio Ferraz Coelho |
author_facet |
Miguel Angel Chávez-Fumagalli Tatiana Gomes Ribeiro Rachel Oliveira Castilho Simone Odília Antunes Fernandes Valbert Nascimento Cardoso Cecília Steinberg Perilo Coelho Débora Vasconcelos Costa Mendonça Manuel Soto Carlos Alberto Pereira Tavares André Augusto Gomes Faraco Eduardo Antonio Ferraz Coelho |
author_sort |
Miguel Angel Chávez-Fumagalli |
title |
New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
title_short |
New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
title_full |
New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
title_fullStr |
New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
title_full_unstemmed |
New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment |
title_sort |
new delivery systems for amphotericin b applied to the improvement of leishmaniasis treatment |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0138-2015 https://doaj.org/article/f8d70aeae8864101872ee0d579e634db |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 3, Pp 235-242 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000300235&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0138-2015 https://doaj.org/article/f8d70aeae8864101872ee0d579e634db |
op_doi |
https://doi.org/10.1590/0037-8682-0138-2015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
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3 |
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235 |
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242 |
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