Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice.
BACKGROUND: The current knowledge of immunological responses to schistosomiasis, a major tropical helminthic disease, is insufficient, and a better understanding of these responses would support vaccine development or therapies to control granuloma-associated immunopathology. CD4(+) T cells play cri...
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ftdoajarticles:oai:doaj.org/article:f8c29d1d11894b1d89b6eafe4d5befc1 2023-05-15T15:16:37+02:00 Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. Xiaoyun Wen Lei He Ying Chi Sha Zhou Jason Hoellwarth Cui Zhang Jifeng Zhu Calvin Wu Shawn Dhesi Xuefeng Wang Feng Liu Chuan Su 2011-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001399 https://doaj.org/article/f8c29d1d11894b1d89b6eafe4d5befc1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3216943?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001399 https://doaj.org/article/f8c29d1d11894b1d89b6eafe4d5befc1 PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1399 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001399 2022-12-31T14:18:45Z BACKGROUND: The current knowledge of immunological responses to schistosomiasis, a major tropical helminthic disease, is insufficient, and a better understanding of these responses would support vaccine development or therapies to control granuloma-associated immunopathology. CD4(+) T cells play critical roles in both host immune responses against parasitic infection and immunopathology in schistosomiasis. The induction of T helper (Th)1, Th2 and T regulatory (Treg) cells and their roles in schistosome infections are well-illustrated. However, little in vivo data are available on the dynamics of Th17 cells, another important CD4(+) T cell subset, after Schistosoma japonicum infection or whether these cells and their defining IL-17 cytokine mediate host protective responses early in infection. METHODOLOGY: Levels of Th17 and the other three CD4(+) T cell subpopulations and the cytokines related to induction or repression of Th17 cell generation in different stages of S. japonicum infection were observed. Contrary to reported in vitro studies, our results showed that the Th17 cells were induced along with the Th1, Th2, Treg cells and the IFN-γ and IL-4 cytokines in S. japonicum infected mice. The results also suggested that S. japonicum egg antigens but not adult worm antigens preferentially induced Th17 cell generation. Furthermore, decreasing IL-17 with a neutralizing anti-IL-17 monoclonal antibody (mAb) increased schistosome-specific antibody levels and partial protection against S. japonicum infection in mice. CONCLUSIONS: Our study is the first to report the dynamics of Th17 cells during S. japonicum infection and indicate that Th17 cell differentiation results from the integrated impact of inducing and suppressive factors promoted by the parasite. Importantly, our findings suggest that lower IL-17 levels may result in favorable host protective responses. This study significantly contributes to the understanding of immunity to schistosomiasis and may aid in developing interventions to protect hosts from ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 11 e1399 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xiaoyun Wen Lei He Ying Chi Sha Zhou Jason Hoellwarth Cui Zhang Jifeng Zhu Calvin Wu Shawn Dhesi Xuefeng Wang Feng Liu Chuan Su Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: The current knowledge of immunological responses to schistosomiasis, a major tropical helminthic disease, is insufficient, and a better understanding of these responses would support vaccine development or therapies to control granuloma-associated immunopathology. CD4(+) T cells play critical roles in both host immune responses against parasitic infection and immunopathology in schistosomiasis. The induction of T helper (Th)1, Th2 and T regulatory (Treg) cells and their roles in schistosome infections are well-illustrated. However, little in vivo data are available on the dynamics of Th17 cells, another important CD4(+) T cell subset, after Schistosoma japonicum infection or whether these cells and their defining IL-17 cytokine mediate host protective responses early in infection. METHODOLOGY: Levels of Th17 and the other three CD4(+) T cell subpopulations and the cytokines related to induction or repression of Th17 cell generation in different stages of S. japonicum infection were observed. Contrary to reported in vitro studies, our results showed that the Th17 cells were induced along with the Th1, Th2, Treg cells and the IFN-γ and IL-4 cytokines in S. japonicum infected mice. The results also suggested that S. japonicum egg antigens but not adult worm antigens preferentially induced Th17 cell generation. Furthermore, decreasing IL-17 with a neutralizing anti-IL-17 monoclonal antibody (mAb) increased schistosome-specific antibody levels and partial protection against S. japonicum infection in mice. CONCLUSIONS: Our study is the first to report the dynamics of Th17 cells during S. japonicum infection and indicate that Th17 cell differentiation results from the integrated impact of inducing and suppressive factors promoted by the parasite. Importantly, our findings suggest that lower IL-17 levels may result in favorable host protective responses. This study significantly contributes to the understanding of immunity to schistosomiasis and may aid in developing interventions to protect hosts from ... |
format |
Article in Journal/Newspaper |
author |
Xiaoyun Wen Lei He Ying Chi Sha Zhou Jason Hoellwarth Cui Zhang Jifeng Zhu Calvin Wu Shawn Dhesi Xuefeng Wang Feng Liu Chuan Su |
author_facet |
Xiaoyun Wen Lei He Ying Chi Sha Zhou Jason Hoellwarth Cui Zhang Jifeng Zhu Calvin Wu Shawn Dhesi Xuefeng Wang Feng Liu Chuan Su |
author_sort |
Xiaoyun Wen |
title |
Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
title_short |
Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
title_full |
Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
title_fullStr |
Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
title_full_unstemmed |
Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. |
title_sort |
dynamics of th17 cells and their role in schistosoma japonicum infection in c57bl/6 mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001399 https://doaj.org/article/f8c29d1d11894b1d89b6eafe4d5befc1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1399 (2011) |
op_relation |
http://europepmc.org/articles/PMC3216943?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001399 https://doaj.org/article/f8c29d1d11894b1d89b6eafe4d5befc1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001399 |
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PLoS Neglected Tropical Diseases |
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5 |
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11 |
container_start_page |
e1399 |
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1766346930072322048 |