Antimalarial drug use in general populations of tropical Africa
Abstract Background The burden of Plasmodium falciparum malaria has worsened because of the emergence of chloroquine resistance. Antimalarial drug use and drug pressure are critical factors contributing to the selection and spread of resistance. The present study explores the geographical, socio-eco...
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ftdoajarticles:oai:doaj.org/article:f8c27b28b09645f395d641eacc229e64 2023-05-15T15:15:31+02:00 Antimalarial drug use in general populations of tropical Africa Gardella Florence Assi Serge Simon Fabrice Bogreau Hervé Eggelte Teunis Ba Fatou Foumane Vincent Henry Marie-Claire Kientega Pélagie Basco Léonardo Trape Jean-François Lalou Richard Martelloni Maryse Desbordes Marc Baragatti Meïli Briolant Sébastien Almeras Lionel Pradines Bruno Fusai Thierry Rogier Christophe 2008-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-124 https://doaj.org/article/f8c27b28b09645f395d641eacc229e64 EN eng BMC http://www.malariajournal.com/content/7/1/124 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-124 1475-2875 https://doaj.org/article/f8c27b28b09645f395d641eacc229e64 Malaria Journal, Vol 7, Iss 1, p 124 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-124 2022-12-31T08:54:58Z Abstract Background The burden of Plasmodium falciparum malaria has worsened because of the emergence of chloroquine resistance. Antimalarial drug use and drug pressure are critical factors contributing to the selection and spread of resistance. The present study explores the geographical, socio-economic and behavioural factors associated with the use of antimalarial drugs in Africa. Methods The presence of chloroquine (CQ), pyrimethamine (PYR) and other antimalarial drugs has been evaluated by immuno-capture and high-performance liquid chromatography in the urine samples of 3,052 children (2–9 y), randomly drawn in 2003 from the general populations at 30 sites in Senegal (10), Burkina-Faso (10) and Cameroon (10). Questionnaires have been administered to the parents of sampled children and to a random sample of households in each site. The presence of CQ in urine was analysed as dependent variable according to individual and site characteristics using a random – effect logistic regression model to take into account the interdependency of observations made within the same site. Results According to the sites, the prevalence rates of CQ and PYR ranged from 9% to 91% and from 0% to 21%, respectively. In multivariate analysis, the presence of CQ in urine was significantly associated with a history of fever during the three days preceding urine sampling (OR = 1.22, p = 0.043), socio-economic level of the population of the sites (OR = 2.74, p = 0.029), age (2–5 y = reference level; 6–9 y OR = 0.76, p = 0.002), prevalence of anti-circumsporozoite protein (CSP) antibodies (low prevalence: reference level; intermediate level OR = 2.47, p = 0.023), proportion of inhabitants who lived in another site one year before (OR = 2.53, p = 0.003), and duration to reach the nearest tarmacked road (duration less than one hour = reference level, duration equal to or more than one hour OR = 0.49, p = 0.019). Conclusion Antimalarial drug pressure varied considerably from one site to another. It was significantly higher in areas with ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 124 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Gardella Florence Assi Serge Simon Fabrice Bogreau Hervé Eggelte Teunis Ba Fatou Foumane Vincent Henry Marie-Claire Kientega Pélagie Basco Léonardo Trape Jean-François Lalou Richard Martelloni Maryse Desbordes Marc Baragatti Meïli Briolant Sébastien Almeras Lionel Pradines Bruno Fusai Thierry Rogier Christophe Antimalarial drug use in general populations of tropical Africa |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The burden of Plasmodium falciparum malaria has worsened because of the emergence of chloroquine resistance. Antimalarial drug use and drug pressure are critical factors contributing to the selection and spread of resistance. The present study explores the geographical, socio-economic and behavioural factors associated with the use of antimalarial drugs in Africa. Methods The presence of chloroquine (CQ), pyrimethamine (PYR) and other antimalarial drugs has been evaluated by immuno-capture and high-performance liquid chromatography in the urine samples of 3,052 children (2–9 y), randomly drawn in 2003 from the general populations at 30 sites in Senegal (10), Burkina-Faso (10) and Cameroon (10). Questionnaires have been administered to the parents of sampled children and to a random sample of households in each site. The presence of CQ in urine was analysed as dependent variable according to individual and site characteristics using a random – effect logistic regression model to take into account the interdependency of observations made within the same site. Results According to the sites, the prevalence rates of CQ and PYR ranged from 9% to 91% and from 0% to 21%, respectively. In multivariate analysis, the presence of CQ in urine was significantly associated with a history of fever during the three days preceding urine sampling (OR = 1.22, p = 0.043), socio-economic level of the population of the sites (OR = 2.74, p = 0.029), age (2–5 y = reference level; 6–9 y OR = 0.76, p = 0.002), prevalence of anti-circumsporozoite protein (CSP) antibodies (low prevalence: reference level; intermediate level OR = 2.47, p = 0.023), proportion of inhabitants who lived in another site one year before (OR = 2.53, p = 0.003), and duration to reach the nearest tarmacked road (duration less than one hour = reference level, duration equal to or more than one hour OR = 0.49, p = 0.019). Conclusion Antimalarial drug pressure varied considerably from one site to another. It was significantly higher in areas with ... |
format |
Article in Journal/Newspaper |
author |
Gardella Florence Assi Serge Simon Fabrice Bogreau Hervé Eggelte Teunis Ba Fatou Foumane Vincent Henry Marie-Claire Kientega Pélagie Basco Léonardo Trape Jean-François Lalou Richard Martelloni Maryse Desbordes Marc Baragatti Meïli Briolant Sébastien Almeras Lionel Pradines Bruno Fusai Thierry Rogier Christophe |
author_facet |
Gardella Florence Assi Serge Simon Fabrice Bogreau Hervé Eggelte Teunis Ba Fatou Foumane Vincent Henry Marie-Claire Kientega Pélagie Basco Léonardo Trape Jean-François Lalou Richard Martelloni Maryse Desbordes Marc Baragatti Meïli Briolant Sébastien Almeras Lionel Pradines Bruno Fusai Thierry Rogier Christophe |
author_sort |
Gardella Florence |
title |
Antimalarial drug use in general populations of tropical Africa |
title_short |
Antimalarial drug use in general populations of tropical Africa |
title_full |
Antimalarial drug use in general populations of tropical Africa |
title_fullStr |
Antimalarial drug use in general populations of tropical Africa |
title_full_unstemmed |
Antimalarial drug use in general populations of tropical Africa |
title_sort |
antimalarial drug use in general populations of tropical africa |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-124 https://doaj.org/article/f8c27b28b09645f395d641eacc229e64 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 124 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/124 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-124 1475-2875 https://doaj.org/article/f8c27b28b09645f395d641eacc229e64 |
op_doi |
https://doi.org/10.1186/1475-2875-7-124 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
container_start_page |
124 |
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1766345892502175744 |