Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules
Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activati...
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ftdoajarticles:oai:doaj.org/article:f8ad4a9bb5be4f8aa717c33c595cf712 2023-05-15T15:37:10+02:00 Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules Kazue Ohishi Tadashi Maruyama Fumio Seki Makoto Takeda 2019-07-01T00:00:00Z https://doi.org/10.3390/v11070606 https://doaj.org/article/f8ad4a9bb5be4f8aa717c33c595cf712 EN eng MDPI AG https://www.mdpi.com/1999-4915/11/7/606 https://doaj.org/toc/1999-4915 1999-4915 doi:10.3390/v11070606 https://doaj.org/article/f8ad4a9bb5be4f8aa717c33c595cf712 Viruses, Vol 11, Iss 7, p 606 (2019) cetacean morbillivirus host specificity marine mammal morbillivirus phocine distemper virus receptor signaling lymphocyte activation molecule Microbiology QR1-502 article 2019 ftdoajarticles https://doi.org/10.3390/v11070606 2022-12-31T12:16:11Z Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activation molecule (SLAM). The three-dimensional crystal structure and homology models of SLAMs have demonstrated that 35 residues are important for binding to the morbillivirus hemagglutinin (H) protein and contribute to viral tropism. These 35 residues are essentially conserved among pinnipeds and highly conserved among the Caniformia, suggesting that PDV can infect these animals, but are less conserved among cetaceans. Because CeMV can infect various cetacean species, including toothed and baleen whales, the CeMV-H protein is postulated to have broader specificity to accommodate more divergent SLAM interfaces and may enable the virus to infect seals. In silico analysis of viral H protein and SLAM indicates that each residue of the H protein interacts with multiple residues of SLAM and vice versa. The integration of epidemiological, virological, structural, and computational studies should provide deeper insight into host specificity and switching of marine morbilliviruses. Article in Journal/Newspaper baleen whales Directory of Open Access Journals: DOAJ Articles Viruses 11 7 606 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cetacean morbillivirus host specificity marine mammal morbillivirus phocine distemper virus receptor signaling lymphocyte activation molecule Microbiology QR1-502 |
spellingShingle |
cetacean morbillivirus host specificity marine mammal morbillivirus phocine distemper virus receptor signaling lymphocyte activation molecule Microbiology QR1-502 Kazue Ohishi Tadashi Maruyama Fumio Seki Makoto Takeda Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
topic_facet |
cetacean morbillivirus host specificity marine mammal morbillivirus phocine distemper virus receptor signaling lymphocyte activation molecule Microbiology QR1-502 |
description |
Epidemiological reports of phocine distemper virus (PDV) and cetacean morbillivirus (CeMV) have accumulated since their discovery nearly 30 years ago. In this review, we focus on the interaction between these marine morbilliviruses and their major cellular receptor, the signaling lymphocyte activation molecule (SLAM). The three-dimensional crystal structure and homology models of SLAMs have demonstrated that 35 residues are important for binding to the morbillivirus hemagglutinin (H) protein and contribute to viral tropism. These 35 residues are essentially conserved among pinnipeds and highly conserved among the Caniformia, suggesting that PDV can infect these animals, but are less conserved among cetaceans. Because CeMV can infect various cetacean species, including toothed and baleen whales, the CeMV-H protein is postulated to have broader specificity to accommodate more divergent SLAM interfaces and may enable the virus to infect seals. In silico analysis of viral H protein and SLAM indicates that each residue of the H protein interacts with multiple residues of SLAM and vice versa. The integration of epidemiological, virological, structural, and computational studies should provide deeper insight into host specificity and switching of marine morbilliviruses. |
format |
Article in Journal/Newspaper |
author |
Kazue Ohishi Tadashi Maruyama Fumio Seki Makoto Takeda |
author_facet |
Kazue Ohishi Tadashi Maruyama Fumio Seki Makoto Takeda |
author_sort |
Kazue Ohishi |
title |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_short |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_full |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_fullStr |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_full_unstemmed |
Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules |
title_sort |
marine morbilliviruses: diversity and interaction with signaling lymphocyte activation molecules |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/v11070606 https://doaj.org/article/f8ad4a9bb5be4f8aa717c33c595cf712 |
genre |
baleen whales |
genre_facet |
baleen whales |
op_source |
Viruses, Vol 11, Iss 7, p 606 (2019) |
op_relation |
https://www.mdpi.com/1999-4915/11/7/606 https://doaj.org/toc/1999-4915 1999-4915 doi:10.3390/v11070606 https://doaj.org/article/f8ad4a9bb5be4f8aa717c33c595cf712 |
op_doi |
https://doi.org/10.3390/v11070606 |
container_title |
Viruses |
container_volume |
11 |
container_issue |
7 |
container_start_page |
606 |
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1766367623573929984 |