Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems

• Published in: International Journal of Molecular Sciences
• Main Authors: Joanna Kolmas, Marcin Sobczak, Ewa Olędzka, Grzegorz Nałęcz-Jawecki, Cezary Dębek
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI AG 2014
• Subjects: polymeric biomaterials; bisphosphonates; polyurethanes; hydroxyapatite; drug delivery systems; clodronate; Biology (General); QH301-705.5; Chemistry; QD1-999; Antarc*; Antarctica
• Online Access: https://doi.org/10.3390/ijms150916831; https://doaj.org/article/f81dafaae04d4d949d41afe4c47138e3

In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.