Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon
Abstract Background Malaria is a growing problem in Africa, with prevalence varies from areas to areas due to several factors including the altitude. This study aimed to investigate the malaria distribution and its relationship with level of some blood parameters and plasma myeloperoxidase (MPO) in...
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ftdoajarticles:oai:doaj.org/article:f80f22255cd94f2b89a2bb4558d5fbfc 2023-05-15T15:17:52+02:00 Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon Ntonifor Helen Ngum Ngahbort Belthine Fakeh Abongwa Edith Lem Oumar Mahamat 2023-01-01T00:00:00Z https://doi.org/10.1186/s12936-022-04438-6 https://doaj.org/article/f80f22255cd94f2b89a2bb4558d5fbfc EN eng BMC https://doi.org/10.1186/s12936-022-04438-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04438-6 1475-2875 https://doaj.org/article/f80f22255cd94f2b89a2bb4558d5fbfc Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023) Altitude Malaria Hemoglobin White blood cells Platelet Myeloperoxidase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-022-04438-6 2023-01-29T01:31:31Z Abstract Background Malaria is a growing problem in Africa, with prevalence varies from areas to areas due to several factors including the altitude. This study aimed to investigate the malaria distribution and its relationship with level of some blood parameters and plasma myeloperoxidase (MPO) in population of three localities with different altitudes. Methods A total of 150 participants were recruited in each locality and facial body temperature of each was measured using a forehead digital thermometer. Blood samples were collected and used diagnose malaria parasite using the rapid test followed by Giemsa stain microscopy and have the full blood count and MPO level using a colorimetric method. Results The overall prevalence of falciparum malaria was 34.7%, with no difference between the three communities, but Bambili of high altitude had the highest prevalence (70.7%). A majority of the infected persons had mild malaria, with most cases being asymptomatic (temperature < 37.5 ºC). Patients had significant increase of geometric mean malaria parasite density (GMPD) in Bambili (1755 ± 216 parasites/µL) and Bamenda (1060 ± 2515 parasites/µL of blood) than patients in Santa (737 ± 799 parasites/µL). There was a significant risk to have malaria infection in Bambili (OR = 33.367, p = 0.021) than in Santa (OR = 2.309, p = 0.362). Bambili’ participants of 6–10 years showed a high prevalence of malaria (85.7%). GMPD was significantly different between males (p = 0.010) as well as females (p = 0.000). Participants from Santa (11.2 ± 3.2 g/dL) and Bambili (12.6 ± 2.4 g/dL) had a high haemoglobin concentration than those from Bamenda (10.6 ± 2.1 g/dL). There was a significant difference in the WBC counts and platelet counts among infected participants in the study areas. MPO level had an increasing trend among infected participants in Santa (2.378 ± 0.250), Bambili (2.582 ± 0.482) and Bamenda (2.635 ± 0.466). Conclusion The results of the present study demonstrated that altitudinal variations significant impact the risk ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Altitude Malaria Hemoglobin White blood cells Platelet Myeloperoxidase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Altitude Malaria Hemoglobin White blood cells Platelet Myeloperoxidase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ntonifor Helen Ngum Ngahbort Belthine Fakeh Abongwa Edith Lem Oumar Mahamat Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
topic_facet |
Altitude Malaria Hemoglobin White blood cells Platelet Myeloperoxidase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is a growing problem in Africa, with prevalence varies from areas to areas due to several factors including the altitude. This study aimed to investigate the malaria distribution and its relationship with level of some blood parameters and plasma myeloperoxidase (MPO) in population of three localities with different altitudes. Methods A total of 150 participants were recruited in each locality and facial body temperature of each was measured using a forehead digital thermometer. Blood samples were collected and used diagnose malaria parasite using the rapid test followed by Giemsa stain microscopy and have the full blood count and MPO level using a colorimetric method. Results The overall prevalence of falciparum malaria was 34.7%, with no difference between the three communities, but Bambili of high altitude had the highest prevalence (70.7%). A majority of the infected persons had mild malaria, with most cases being asymptomatic (temperature < 37.5 ºC). Patients had significant increase of geometric mean malaria parasite density (GMPD) in Bambili (1755 ± 216 parasites/µL) and Bamenda (1060 ± 2515 parasites/µL of blood) than patients in Santa (737 ± 799 parasites/µL). There was a significant risk to have malaria infection in Bambili (OR = 33.367, p = 0.021) than in Santa (OR = 2.309, p = 0.362). Bambili’ participants of 6–10 years showed a high prevalence of malaria (85.7%). GMPD was significantly different between males (p = 0.010) as well as females (p = 0.000). Participants from Santa (11.2 ± 3.2 g/dL) and Bambili (12.6 ± 2.4 g/dL) had a high haemoglobin concentration than those from Bamenda (10.6 ± 2.1 g/dL). There was a significant difference in the WBC counts and platelet counts among infected participants in the study areas. MPO level had an increasing trend among infected participants in Santa (2.378 ± 0.250), Bambili (2.582 ± 0.482) and Bamenda (2.635 ± 0.466). Conclusion The results of the present study demonstrated that altitudinal variations significant impact the risk ... |
format |
Article in Journal/Newspaper |
author |
Ntonifor Helen Ngum Ngahbort Belthine Fakeh Abongwa Edith Lem Oumar Mahamat |
author_facet |
Ntonifor Helen Ngum Ngahbort Belthine Fakeh Abongwa Edith Lem Oumar Mahamat |
author_sort |
Ntonifor Helen Ngum |
title |
Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
title_short |
Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
title_full |
Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
title_fullStr |
Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
title_full_unstemmed |
Prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of Mezam division, North West Region, Cameroon |
title_sort |
prevalence of malaria and associated clinical manifestations and myeloperoxidase amongst populations living in different altitudes of mezam division, north west region, cameroon |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-022-04438-6 https://doaj.org/article/f80f22255cd94f2b89a2bb4558d5fbfc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023) |
op_relation |
https://doi.org/10.1186/s12936-022-04438-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04438-6 1475-2875 https://doaj.org/article/f80f22255cd94f2b89a2bb4558d5fbfc |
op_doi |
https://doi.org/10.1186/s12936-022-04438-6 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
_version_ |
1766348122875756544 |