Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
Abstract The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase....
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ftdoajarticles:oai:doaj.org/article:f80cd69892fc46799076b35caabf8c7a 2023-05-15T15:05:16+02:00 Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine Mikus Gerd Walter-Sack Ingeborg Jahn Albrecht Schiek Wolfgang Rengelshausen Jens Mansmann Ulrich Tapsoba Théophile Witte Steffen Coulibaly Boubacar Mandi Germain Meissner Peter E Burhenne Jürgen Riedel Klaus-Dieter Schirmer R Heiner Kouyaté Bocar Müller Olaf 2006-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-5-84 https://doaj.org/article/f80cd69892fc46799076b35caabf8c7a EN eng BMC http://www.malariajournal.com/content/5/1/84 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-84 1475-2875 https://doaj.org/article/f80cd69892fc46799076b35caabf8c7a Malaria Journal, Vol 5, Iss 1, p 84 (2006) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2006 ftdoajarticles https://doi.org/10.1186/1475-2875-5-84 2022-12-31T04:25:02Z Abstract The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 5 1 84 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Mikus Gerd Walter-Sack Ingeborg Jahn Albrecht Schiek Wolfgang Rengelshausen Jens Mansmann Ulrich Tapsoba Théophile Witte Steffen Coulibaly Boubacar Mandi Germain Meissner Peter E Burhenne Jürgen Riedel Klaus-Dieter Schirmer R Heiner Kouyaté Bocar Müller Olaf Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa. |
format |
Article in Journal/Newspaper |
author |
Mikus Gerd Walter-Sack Ingeborg Jahn Albrecht Schiek Wolfgang Rengelshausen Jens Mansmann Ulrich Tapsoba Théophile Witte Steffen Coulibaly Boubacar Mandi Germain Meissner Peter E Burhenne Jürgen Riedel Klaus-Dieter Schirmer R Heiner Kouyaté Bocar Müller Olaf |
author_facet |
Mikus Gerd Walter-Sack Ingeborg Jahn Albrecht Schiek Wolfgang Rengelshausen Jens Mansmann Ulrich Tapsoba Théophile Witte Steffen Coulibaly Boubacar Mandi Germain Meissner Peter E Burhenne Jürgen Riedel Klaus-Dieter Schirmer R Heiner Kouyaté Bocar Müller Olaf |
author_sort |
Mikus Gerd |
title |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
title_short |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
title_full |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
title_fullStr |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
title_full_unstemmed |
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine |
title_sort |
methylene blue for malaria in africa: results from a dose-finding study in combination with chloroquine |
publisher |
BMC |
publishDate |
2006 |
url |
https://doi.org/10.1186/1475-2875-5-84 https://doaj.org/article/f80cd69892fc46799076b35caabf8c7a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 5, Iss 1, p 84 (2006) |
op_relation |
http://www.malariajournal.com/content/5/1/84 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-84 1475-2875 https://doaj.org/article/f80cd69892fc46799076b35caabf8c7a |
op_doi |
https://doi.org/10.1186/1475-2875-5-84 |
container_title |
Malaria Journal |
container_volume |
5 |
container_issue |
1 |
container_start_page |
84 |
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1766337004589547520 |