Helminth genomics: The implications for human health.
More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, los...
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ftdoajarticles:oai:doaj.org/article:f80c0f5c37b848fabf3122fbb186ec7b 2023-05-15T15:05:44+02:00 Helminth genomics: The implications for human health. Paul J Brindley Makedonka Mitreva Elodie Ghedin Sara Lustigman 2009-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000538 https://doaj.org/article/f80c0f5c37b848fabf3122fbb186ec7b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2757907?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000538 https://doaj.org/article/f80c0f5c37b848fabf3122fbb186ec7b PLoS Neglected Tropical Diseases, Vol 3, Iss 10, p e538 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000538 2022-12-31T15:53:31Z More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 10 e538 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Paul J Brindley Makedonka Mitreva Elodie Ghedin Sara Lustigman Helminth genomics: The implications for human health. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings. |
format |
Article in Journal/Newspaper |
author |
Paul J Brindley Makedonka Mitreva Elodie Ghedin Sara Lustigman |
author_facet |
Paul J Brindley Makedonka Mitreva Elodie Ghedin Sara Lustigman |
author_sort |
Paul J Brindley |
title |
Helminth genomics: The implications for human health. |
title_short |
Helminth genomics: The implications for human health. |
title_full |
Helminth genomics: The implications for human health. |
title_fullStr |
Helminth genomics: The implications for human health. |
title_full_unstemmed |
Helminth genomics: The implications for human health. |
title_sort |
helminth genomics: the implications for human health. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000538 https://doaj.org/article/f80c0f5c37b848fabf3122fbb186ec7b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 10, p e538 (2009) |
op_relation |
http://europepmc.org/articles/PMC2757907?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000538 https://doaj.org/article/f80c0f5c37b848fabf3122fbb186ec7b |
op_doi |
https://doi.org/10.1371/journal.pntd.0000538 |
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PLoS Neglected Tropical Diseases |
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3 |
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10 |
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e538 |
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1766337376615923712 |