Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.
Background Flavivirus infections pose a significant global health burden underscoring the need for the development of safe and effective vaccination strategies. Available flavivirus vaccines are from time to time concomitantly delivered to individuals. Co-administration of different vaccines saves t...
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Online Access: | https://doi.org/10.1371/journal.pntd.0010616 https://doaj.org/article/f7d4a94440c0457bb19dfb5d2706a871 |
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ftdoajarticles:oai:doaj.org/article:f7d4a94440c0457bb19dfb5d2706a871 2023-05-15T15:15:08+02:00 Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. John Tyler Sandberg Marie Löfling Renata Varnaitė Johanna Emgård Nabil Al-Tawil Lars Lindquist Sara Gredmark-Russ Jonas Klingström Karin Loré Kim Blom Hans-Gustaf Ljunggren 2023-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010616 https://doaj.org/article/f7d4a94440c0457bb19dfb5d2706a871 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010616 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010616 https://doaj.org/article/f7d4a94440c0457bb19dfb5d2706a871 PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0010616 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010616 2023-03-05T01:33:15Z Background Flavivirus infections pose a significant global health burden underscoring the need for the development of safe and effective vaccination strategies. Available flavivirus vaccines are from time to time concomitantly delivered to individuals. Co-administration of different vaccines saves time and visits to health care units and vaccine clinics. It serves to provide protection against multiple pathogens in a shorter time-span; e.g., for individuals travelling to different endemic areas. However, safety and immunogenicity-related responses have not been appropriately evaluated upon concomitant delivery of these vaccines. Therefore, we performed an open label, non-randomized clinical trial studying the safety and immunogenicity following concomitant delivery of the yellow fever virus (YFV) vaccine with tick-borne encephalitis virus (TBEV) and Japanese encephalitis virus (JE) virus vaccines. Methods and findings Following screening, healthy study participants were enrolled into different cohorts receiving either TBEV and YFV vaccines, JEV and YFV vaccines, or in control groups receiving only the TBEV, JEV, or YFV vaccine. Concomitant delivery was given in the same or different upper arms for comparison in the co-vaccination cohorts. Adverse effects were recorded throughout the study period and blood samples were taken before and at multiple time-points following vaccination to evaluate immunological responses to the vaccines. Adverse events were predominantly mild in the study groups. Four serious adverse events (SAE) were reported, none of them deemed related to vaccination. The development of neutralizing antibodies (nAbs) against TBEV, JEV, or YFV was not affected by the concomitant vaccination strategy. Concomitant vaccination in the same or different upper arms did not significantly affect safety or immunogenicity-related outcomes. Exploratory studies on immunological effects were additionally performed and included studies of lymphocyte activation, correlates associated with germinal center ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 2 e0010616 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 John Tyler Sandberg Marie Löfling Renata Varnaitė Johanna Emgård Nabil Al-Tawil Lars Lindquist Sara Gredmark-Russ Jonas Klingström Karin Loré Kim Blom Hans-Gustaf Ljunggren Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Flavivirus infections pose a significant global health burden underscoring the need for the development of safe and effective vaccination strategies. Available flavivirus vaccines are from time to time concomitantly delivered to individuals. Co-administration of different vaccines saves time and visits to health care units and vaccine clinics. It serves to provide protection against multiple pathogens in a shorter time-span; e.g., for individuals travelling to different endemic areas. However, safety and immunogenicity-related responses have not been appropriately evaluated upon concomitant delivery of these vaccines. Therefore, we performed an open label, non-randomized clinical trial studying the safety and immunogenicity following concomitant delivery of the yellow fever virus (YFV) vaccine with tick-borne encephalitis virus (TBEV) and Japanese encephalitis virus (JE) virus vaccines. Methods and findings Following screening, healthy study participants were enrolled into different cohorts receiving either TBEV and YFV vaccines, JEV and YFV vaccines, or in control groups receiving only the TBEV, JEV, or YFV vaccine. Concomitant delivery was given in the same or different upper arms for comparison in the co-vaccination cohorts. Adverse effects were recorded throughout the study period and blood samples were taken before and at multiple time-points following vaccination to evaluate immunological responses to the vaccines. Adverse events were predominantly mild in the study groups. Four serious adverse events (SAE) were reported, none of them deemed related to vaccination. The development of neutralizing antibodies (nAbs) against TBEV, JEV, or YFV was not affected by the concomitant vaccination strategy. Concomitant vaccination in the same or different upper arms did not significantly affect safety or immunogenicity-related outcomes. Exploratory studies on immunological effects were additionally performed and included studies of lymphocyte activation, correlates associated with germinal center ... |
format |
Article in Journal/Newspaper |
author |
John Tyler Sandberg Marie Löfling Renata Varnaitė Johanna Emgård Nabil Al-Tawil Lars Lindquist Sara Gredmark-Russ Jonas Klingström Karin Loré Kim Blom Hans-Gustaf Ljunggren |
author_facet |
John Tyler Sandberg Marie Löfling Renata Varnaitė Johanna Emgård Nabil Al-Tawil Lars Lindquist Sara Gredmark-Russ Jonas Klingström Karin Loré Kim Blom Hans-Gustaf Ljunggren |
author_sort |
John Tyler Sandberg |
title |
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
title_short |
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
title_full |
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
title_fullStr |
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
title_full_unstemmed |
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial. |
title_sort |
safety and immunogenicity following co-administration of yellow fever vaccine with tick-borne encephalitis or japanese encephalitis vaccines: results from an open label, non-randomized clinical trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0010616 https://doaj.org/article/f7d4a94440c0457bb19dfb5d2706a871 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0010616 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010616 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010616 https://doaj.org/article/f7d4a94440c0457bb19dfb5d2706a871 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010616 |
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PLOS Neglected Tropical Diseases |
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e0010616 |
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