Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army.
In Colombia, the cutaneous leishmaniasis (CL) is the most common manifestation across the army personnel. Hence, it is mandatory to determine the species associated with the disease as well as the association with the clinical traits. A total of 273 samples of male patients with CL were included in...
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ftdoajarticles:oai:doaj.org/article:f7ae6999ffcd4c838c8dd223d3d779a7 2023-05-15T15:08:31+02:00 Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. Luz H Patino Claudia Mendez Omaira Rodriguez Yanira Romero Daniel Velandia Maria Alvarado Julie Pérez Maria Clara Duque Juan David Ramírez 2017-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005876 https://doaj.org/article/f7ae6999ffcd4c838c8dd223d3d779a7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5593196?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005876 https://doaj.org/article/f7ae6999ffcd4c838c8dd223d3d779a7 PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005876 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005876 2022-12-31T09:49:45Z In Colombia, the cutaneous leishmaniasis (CL) is the most common manifestation across the army personnel. Hence, it is mandatory to determine the species associated with the disease as well as the association with the clinical traits. A total of 273 samples of male patients with CL were included in the study and clinical data of the patients was studied. PCR and sequencing analyses (Cytb and HSP70 genes) were performed to identify the species and the intra-specific genetic variability. A georeferenced database was constructed to identify the spatial distribution of Leishmania species isolated. The identification of five species of Leishmania that circulate in the areas where army personnel are deployed is described. Predominant infecting Leishmania species corresponds to L. braziliensis (61.1%), followed by Leishmania panamensis (33.5%), with a high distribution of both species at geographical and municipal level. The species L. guyanensis, L. mexicana and L. lainsoni were also detected at lower frequency. We also showed the identification of different genotypes within L. braziliensis and L. panamensis. In conclusion, we identified the Leishmania species circulating in the areas where Colombian army personnel are deployed, as well as the high intra-specific genetic variability of L. braziliensis and L. panamensis and how these genotypes are distributed at the geographic level. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 8 e0005876 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Luz H Patino Claudia Mendez Omaira Rodriguez Yanira Romero Daniel Velandia Maria Alvarado Julie Pérez Maria Clara Duque Juan David Ramírez Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In Colombia, the cutaneous leishmaniasis (CL) is the most common manifestation across the army personnel. Hence, it is mandatory to determine the species associated with the disease as well as the association with the clinical traits. A total of 273 samples of male patients with CL were included in the study and clinical data of the patients was studied. PCR and sequencing analyses (Cytb and HSP70 genes) were performed to identify the species and the intra-specific genetic variability. A georeferenced database was constructed to identify the spatial distribution of Leishmania species isolated. The identification of five species of Leishmania that circulate in the areas where army personnel are deployed is described. Predominant infecting Leishmania species corresponds to L. braziliensis (61.1%), followed by Leishmania panamensis (33.5%), with a high distribution of both species at geographical and municipal level. The species L. guyanensis, L. mexicana and L. lainsoni were also detected at lower frequency. We also showed the identification of different genotypes within L. braziliensis and L. panamensis. In conclusion, we identified the Leishmania species circulating in the areas where Colombian army personnel are deployed, as well as the high intra-specific genetic variability of L. braziliensis and L. panamensis and how these genotypes are distributed at the geographic level. |
format |
Article in Journal/Newspaper |
author |
Luz H Patino Claudia Mendez Omaira Rodriguez Yanira Romero Daniel Velandia Maria Alvarado Julie Pérez Maria Clara Duque Juan David Ramírez |
author_facet |
Luz H Patino Claudia Mendez Omaira Rodriguez Yanira Romero Daniel Velandia Maria Alvarado Julie Pérez Maria Clara Duque Juan David Ramírez |
author_sort |
Luz H Patino |
title |
Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
title_short |
Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
title_full |
Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
title_fullStr |
Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
title_full_unstemmed |
Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. |
title_sort |
spatial distribution, leishmania species and clinical traits of cutaneous leishmaniasis cases in the colombian army. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005876 https://doaj.org/article/f7ae6999ffcd4c838c8dd223d3d779a7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005876 (2017) |
op_relation |
http://europepmc.org/articles/PMC5593196?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005876 https://doaj.org/article/f7ae6999ffcd4c838c8dd223d3d779a7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005876 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
8 |
container_start_page |
e0005876 |
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