No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland
Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring’s birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring’...
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ftdoajarticles:oai:doaj.org/article:f7a17b79ab534cdaab52cac892bcf775 2023-05-15T15:09:27+02:00 No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland Katja Vedsted Rasmussen Karoline Kragelund Nielsen Michael Lynge Pedersen 2020-01-01T00:00:00Z https://doi.org/10.1080/22423982.2019.1702798 https://doaj.org/article/f7a17b79ab534cdaab52cac892bcf775 EN eng Taylor & Francis Group http://dx.doi.org/10.1080/22423982.2019.1702798 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2019.1702798 https://doaj.org/article/f7a17b79ab534cdaab52cac892bcf775 International Journal of Circumpolar Health, Vol 79, Iss 1 (2020) glycosylated haemoglobin birthweight pregnancy greenland Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1080/22423982.2019.1702798 2022-12-31T12:41:55Z Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring’s birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring’s birthweight among predominantly indigenous women in Greenland. A retrospective cohort study including all women (n = 503) and their offspring delivered from September 2015 to September 2016 at Queen Ingrid’s Hospital in Nuuk was conducted. Data were obtained from the electronic medical record. Linear regression models were used to analyse the effect of maternal HbA1c on the offspring’s birthweight with adjustment and stratification for relevant confounders and effect modifiers. Birthweight increased with 3.3 g per mmol/mol increase in HbA1c. Yet, no significant association between maternal HbA1c and the offspring’s birthweight was found after adjustment for maternal age, ethnicity, residence, smoking, and parity (β = 0.058, p = 0.711). Among obese women, a borderline significant positive association (β = 0.657, p = 0.059) was found. For term newborns, this corresponded to an increase in birthweight of 31 g per mmol/mol increase in HbA1c. Based on the current study, the use of HbA1c during pregnancy to detect the risk of delivering a newborn with macrosomia is not recommended in Greenland. Abbreviation: HbA1c: glycosylated haemoglobin; GA: gestational age; SD: standard deviation; CI: confidence interval. Article in Journal/Newspaper Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk Directory of Open Access Journals: DOAJ Articles Arctic Greenland Nuuk ENVELOPE(-52.150,-52.150,68.717,68.717) International Journal of Circumpolar Health 79 1 1702798 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
glycosylated haemoglobin birthweight pregnancy greenland Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
glycosylated haemoglobin birthweight pregnancy greenland Arctic medicine. Tropical medicine RC955-962 Katja Vedsted Rasmussen Karoline Kragelund Nielsen Michael Lynge Pedersen No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
topic_facet |
glycosylated haemoglobin birthweight pregnancy greenland Arctic medicine. Tropical medicine RC955-962 |
description |
Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring’s birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring’s birthweight among predominantly indigenous women in Greenland. A retrospective cohort study including all women (n = 503) and their offspring delivered from September 2015 to September 2016 at Queen Ingrid’s Hospital in Nuuk was conducted. Data were obtained from the electronic medical record. Linear regression models were used to analyse the effect of maternal HbA1c on the offspring’s birthweight with adjustment and stratification for relevant confounders and effect modifiers. Birthweight increased with 3.3 g per mmol/mol increase in HbA1c. Yet, no significant association between maternal HbA1c and the offspring’s birthweight was found after adjustment for maternal age, ethnicity, residence, smoking, and parity (β = 0.058, p = 0.711). Among obese women, a borderline significant positive association (β = 0.657, p = 0.059) was found. For term newborns, this corresponded to an increase in birthweight of 31 g per mmol/mol increase in HbA1c. Based on the current study, the use of HbA1c during pregnancy to detect the risk of delivering a newborn with macrosomia is not recommended in Greenland. Abbreviation: HbA1c: glycosylated haemoglobin; GA: gestational age; SD: standard deviation; CI: confidence interval. |
format |
Article in Journal/Newspaper |
author |
Katja Vedsted Rasmussen Karoline Kragelund Nielsen Michael Lynge Pedersen |
author_facet |
Katja Vedsted Rasmussen Karoline Kragelund Nielsen Michael Lynge Pedersen |
author_sort |
Katja Vedsted Rasmussen |
title |
No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
title_short |
No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
title_full |
No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
title_fullStr |
No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
title_full_unstemmed |
No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland |
title_sort |
no association between early maternal hba1c and offspring birthweight among women without pre-existing diabetes in greenland |
publisher |
Taylor & Francis Group |
publishDate |
2020 |
url |
https://doi.org/10.1080/22423982.2019.1702798 https://doaj.org/article/f7a17b79ab534cdaab52cac892bcf775 |
long_lat |
ENVELOPE(-52.150,-52.150,68.717,68.717) |
geographic |
Arctic Greenland Nuuk |
geographic_facet |
Arctic Greenland Nuuk |
genre |
Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk |
genre_facet |
Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk |
op_source |
International Journal of Circumpolar Health, Vol 79, Iss 1 (2020) |
op_relation |
http://dx.doi.org/10.1080/22423982.2019.1702798 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2019.1702798 https://doaj.org/article/f7a17b79ab534cdaab52cac892bcf775 |
op_doi |
https://doi.org/10.1080/22423982.2019.1702798 |
container_title |
International Journal of Circumpolar Health |
container_volume |
79 |
container_issue |
1 |
container_start_page |
1702798 |
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1766340647964377088 |