Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut
Objective: Infectious illness, including lower respiratory tract infection (LRTI), is a leading cause of childhood morbidity and infant mortality in Inuit children in Nunavut Canada. The carnitine palmitoyltransferase 1A (CPT1A) p.P479L variant is common in arctic Indigenous populations of Alaska, C...
Published in: | Frontiers in Pediatrics |
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Language: | English |
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Frontiers Media S.A.
2021
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Online Access: | https://doi.org/10.3389/fped.2021.678553 https://doaj.org/article/f75e9481d76c43b19b31dcc174ede376 |
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ftdoajarticles:oai:doaj.org/article:f75e9481d76c43b19b31dcc174ede376 2023-05-15T15:02:01+02:00 Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut Sorcha A. Collins Sharon Edmunds Gwen Healey Akearok J. Robert Thompson Anders C. Erickson Elske Hildes-Ripstein Amber Miners Martin Somerville David M. Goldfarb Cheryl Rockman-Greenberg Laura Arbour 2021-07-01T00:00:00Z https://doi.org/10.3389/fped.2021.678553 https://doaj.org/article/f75e9481d76c43b19b31dcc174ede376 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fped.2021.678553/full https://doaj.org/toc/2296-2360 2296-2360 doi:10.3389/fped.2021.678553 https://doaj.org/article/f75e9481d76c43b19b31dcc174ede376 Frontiers in Pediatrics, Vol 9 (2021) Indigenous Inuit carnitine palmitoyltransferase 1A infectious illness p.P479L arctic variant respiratory tract infection in children Pediatrics RJ1-570 article 2021 ftdoajarticles https://doi.org/10.3389/fped.2021.678553 2022-12-31T05:30:36Z Objective: Infectious illness, including lower respiratory tract infection (LRTI), is a leading cause of childhood morbidity and infant mortality in Inuit children in Nunavut Canada. The carnitine palmitoyltransferase 1A (CPT1A) p.P479L variant is common in arctic Indigenous populations of Alaska, Canada, and Greenland. CPT1A is a fatty acid oxidation enzyme expressed in the liver, immunocytes and other tissues, and is needed to use fats for energy during fasting. Previous association of the variant with early childhood infectious illness and infant death has been challenged because of sample size and limited adjustment for confounders. We evaluated whether the p.P479L variant is associated with infectious illness in Inuit children of Nunavut, Canada.Methods: We conducted a retrospective clinical chart review of 2,225 Inuit children (0–5 years) for infectious illness (including otitis media, gastroenteritis, and hospital admission for LRTI), prenatal, perinatal, and socioeconomic indicators, subsequently linking to CPT1A genotype. Multivariable logistic regression adjusted for birth characteristics, breastfeeding, maternal smoking, food insecurity, and socioeconomic indicators.Results: Overall, 27% of children were hospitalized for LRTI, 86% had otitis media and 50% had gastroenteritis. The p.P479L allele frequency was 0.82. In multivariable analysis, p.P479L homozygosity was associated with LRTI admission (aOR:2.88 95%CI:1.46–5.64), otitis media (aOR:1.83, 95%CI:1.05–3.21), and gastroenteritis (aOR:1.74, 95%CI:1.09–2.77), compared to non-carriers.Conclusion: Children homozygous for the p.P479L variant were more likely to experience infectious illness than non-carriers, including hospitalization for respiratory tract infections. Given the role of CPT1A in immunocytes, our findings indicate that more study is needed to determine if there is a role of the variant in immune response. Continued Inuit involvement is essential when considering next steps. Article in Journal/Newspaper Arctic Greenland inuit Nunavut Alaska Directory of Open Access Journals: DOAJ Articles Arctic Nunavut Canada Greenland Frontiers in Pediatrics 9 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Indigenous Inuit carnitine palmitoyltransferase 1A infectious illness p.P479L arctic variant respiratory tract infection in children Pediatrics RJ1-570 |
spellingShingle |
Indigenous Inuit carnitine palmitoyltransferase 1A infectious illness p.P479L arctic variant respiratory tract infection in children Pediatrics RJ1-570 Sorcha A. Collins Sharon Edmunds Gwen Healey Akearok J. Robert Thompson Anders C. Erickson Elske Hildes-Ripstein Amber Miners Martin Somerville David M. Goldfarb Cheryl Rockman-Greenberg Laura Arbour Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
topic_facet |
Indigenous Inuit carnitine palmitoyltransferase 1A infectious illness p.P479L arctic variant respiratory tract infection in children Pediatrics RJ1-570 |
description |
Objective: Infectious illness, including lower respiratory tract infection (LRTI), is a leading cause of childhood morbidity and infant mortality in Inuit children in Nunavut Canada. The carnitine palmitoyltransferase 1A (CPT1A) p.P479L variant is common in arctic Indigenous populations of Alaska, Canada, and Greenland. CPT1A is a fatty acid oxidation enzyme expressed in the liver, immunocytes and other tissues, and is needed to use fats for energy during fasting. Previous association of the variant with early childhood infectious illness and infant death has been challenged because of sample size and limited adjustment for confounders. We evaluated whether the p.P479L variant is associated with infectious illness in Inuit children of Nunavut, Canada.Methods: We conducted a retrospective clinical chart review of 2,225 Inuit children (0–5 years) for infectious illness (including otitis media, gastroenteritis, and hospital admission for LRTI), prenatal, perinatal, and socioeconomic indicators, subsequently linking to CPT1A genotype. Multivariable logistic regression adjusted for birth characteristics, breastfeeding, maternal smoking, food insecurity, and socioeconomic indicators.Results: Overall, 27% of children were hospitalized for LRTI, 86% had otitis media and 50% had gastroenteritis. The p.P479L allele frequency was 0.82. In multivariable analysis, p.P479L homozygosity was associated with LRTI admission (aOR:2.88 95%CI:1.46–5.64), otitis media (aOR:1.83, 95%CI:1.05–3.21), and gastroenteritis (aOR:1.74, 95%CI:1.09–2.77), compared to non-carriers.Conclusion: Children homozygous for the p.P479L variant were more likely to experience infectious illness than non-carriers, including hospitalization for respiratory tract infections. Given the role of CPT1A in immunocytes, our findings indicate that more study is needed to determine if there is a role of the variant in immune response. Continued Inuit involvement is essential when considering next steps. |
format |
Article in Journal/Newspaper |
author |
Sorcha A. Collins Sharon Edmunds Gwen Healey Akearok J. Robert Thompson Anders C. Erickson Elske Hildes-Ripstein Amber Miners Martin Somerville David M. Goldfarb Cheryl Rockman-Greenberg Laura Arbour |
author_facet |
Sorcha A. Collins Sharon Edmunds Gwen Healey Akearok J. Robert Thompson Anders C. Erickson Elske Hildes-Ripstein Amber Miners Martin Somerville David M. Goldfarb Cheryl Rockman-Greenberg Laura Arbour |
author_sort |
Sorcha A. Collins |
title |
Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
title_short |
Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
title_full |
Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
title_fullStr |
Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
title_full_unstemmed |
Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut |
title_sort |
association of the cpt1a p.p479l metabolic gene variant with childhood respiratory and other infectious illness in nunavut |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doi.org/10.3389/fped.2021.678553 https://doaj.org/article/f75e9481d76c43b19b31dcc174ede376 |
geographic |
Arctic Nunavut Canada Greenland |
geographic_facet |
Arctic Nunavut Canada Greenland |
genre |
Arctic Greenland inuit Nunavut Alaska |
genre_facet |
Arctic Greenland inuit Nunavut Alaska |
op_source |
Frontiers in Pediatrics, Vol 9 (2021) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fped.2021.678553/full https://doaj.org/toc/2296-2360 2296-2360 doi:10.3389/fped.2021.678553 https://doaj.org/article/f75e9481d76c43b19b31dcc174ede376 |
op_doi |
https://doi.org/10.3389/fped.2021.678553 |
container_title |
Frontiers in Pediatrics |
container_volume |
9 |
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1766334021940281344 |