Involvement of the autonomic nervous system in Chagas heart disease
The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1983
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ftdoajarticles:oai:doaj.org/article:f74fa25cddeb4135958bf936978829af 2023-05-15T15:16:16+02:00 Involvement of the autonomic nervous system in Chagas heart disease Edison Reis Lopes Washington Luiz Tafuri 1983-12-01T00:00:00Z https://doaj.org/article/f74fa25cddeb4135958bf936978829af EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000400007 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/f74fa25cddeb4135958bf936978829af Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 4, Pp 206-212 (1983) Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Chagas' disease Trypanosomiasis cruzi Chagas' heart disease Autonomic nervous system Arctic medicine. Tropical medicine RC955-962 article 1983 ftdoajarticles 2022-12-30T23:18:01Z The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and; 3) Those dying as a consequence ofaccidents or homicide. Hearts in the threegroups also revealed myocarditis and scattered involvement of intramyocardial ganglion cells as well as lesions of myelinic and unmyelinic fibers ascribable to Chagas'disease. In mice with experimentally induced Chagas' disease weobserved more intensive neuronal lesions of the cardiac ganglia in the acute phase of infection. Perhaps neuronal loss has a role in the pathogenesis of Chagas cardiomyopathy. However based on our own experience and on other data from the literature we conclude that the loss of neurones is not the main factor responsible for the manifestations exhibited by chronic chagasic patients. On the other hand the neuronal lesions may have played a role in the sudden death ofone group of patients with Chagas'disease but is difficult to explain the group of patients who did not die sudderly but instead progressed to cardiac failure. O sistema nervoso autônomo e especialmente o sistema nervoso autônomo intracardiaco são lesados na doença de Chagas. Ganglionite e periganglionite foram observadas em 1) chagásicos com insuficiência cardíaca; 2} em tripanossomóticos, assintomáticos ou paucissintomáticos, em vida, falecidos subitamente em conseqüência da doença de Chagas e 3) nos chagásicos, também assintomáticos, e que faleceram devido a acidentes ou homicídios. Em todos os três grupos os corações mostraram miocardite e lesões das células ganglionares intramiocárdicas bem como das fibras nervosas mielínicas e amielínicas. Em camundongos com infecção chagásica experimental, observamos que na fase aguda da doença as lesões são mais graves e intensas. A denervação talvez desempenhe algum papel na patogênese da cardiopatia chagásica. Entretanto, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Chagas' disease Trypanosomiasis cruzi Chagas' heart disease Autonomic nervous system Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Chagas' disease Trypanosomiasis cruzi Chagas' heart disease Autonomic nervous system Arctic medicine. Tropical medicine RC955-962 Edison Reis Lopes Washington Luiz Tafuri Involvement of the autonomic nervous system in Chagas heart disease |
topic_facet |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Chagas' disease Trypanosomiasis cruzi Chagas' heart disease Autonomic nervous system Arctic medicine. Tropical medicine RC955-962 |
description |
The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and; 3) Those dying as a consequence ofaccidents or homicide. Hearts in the threegroups also revealed myocarditis and scattered involvement of intramyocardial ganglion cells as well as lesions of myelinic and unmyelinic fibers ascribable to Chagas'disease. In mice with experimentally induced Chagas' disease weobserved more intensive neuronal lesions of the cardiac ganglia in the acute phase of infection. Perhaps neuronal loss has a role in the pathogenesis of Chagas cardiomyopathy. However based on our own experience and on other data from the literature we conclude that the loss of neurones is not the main factor responsible for the manifestations exhibited by chronic chagasic patients. On the other hand the neuronal lesions may have played a role in the sudden death ofone group of patients with Chagas'disease but is difficult to explain the group of patients who did not die sudderly but instead progressed to cardiac failure. O sistema nervoso autônomo e especialmente o sistema nervoso autônomo intracardiaco são lesados na doença de Chagas. Ganglionite e periganglionite foram observadas em 1) chagásicos com insuficiência cardíaca; 2} em tripanossomóticos, assintomáticos ou paucissintomáticos, em vida, falecidos subitamente em conseqüência da doença de Chagas e 3) nos chagásicos, também assintomáticos, e que faleceram devido a acidentes ou homicídios. Em todos os três grupos os corações mostraram miocardite e lesões das células ganglionares intramiocárdicas bem como das fibras nervosas mielínicas e amielínicas. Em camundongos com infecção chagásica experimental, observamos que na fase aguda da doença as lesões são mais graves e intensas. A denervação talvez desempenhe algum papel na patogênese da cardiopatia chagásica. Entretanto, ... |
format |
Article in Journal/Newspaper |
author |
Edison Reis Lopes Washington Luiz Tafuri |
author_facet |
Edison Reis Lopes Washington Luiz Tafuri |
author_sort |
Edison Reis Lopes |
title |
Involvement of the autonomic nervous system in Chagas heart disease |
title_short |
Involvement of the autonomic nervous system in Chagas heart disease |
title_full |
Involvement of the autonomic nervous system in Chagas heart disease |
title_fullStr |
Involvement of the autonomic nervous system in Chagas heart disease |
title_full_unstemmed |
Involvement of the autonomic nervous system in Chagas heart disease |
title_sort |
involvement of the autonomic nervous system in chagas heart disease |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1983 |
url |
https://doaj.org/article/f74fa25cddeb4135958bf936978829af |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Aguda |
geographic_facet |
Arctic Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 4, Pp 206-212 (1983) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000400007 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/f74fa25cddeb4135958bf936978829af |
_version_ |
1766346550646145024 |