Role of genetic factors in the development of metabolic and immune response in the cases of acute respiratory infections complicated by pneumonia in the conditions of the far north in various ethnic groups

• Main Authors: V. V. Ivanova, L. V. Govorova, A. V. Erbasskaya, G. F. Zheleznikova
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Journal Infectology 2014
• Subjects: острые респираторные инфекции; пневмонии; якуты; русские; тип ацетилирования; свободно-радикальное окисление; гормон роста (стг); кортизол; cd+ (3; 4; 8; 16; 25; 95); иммуноглобулины (ig a; ig m; igg); Infectious and parasitic diseases; RC109-216; Sakha; Sakha Republic; Yakuts
• Online Access: https://doi.org/10.22625/2072-6732-2012-4-1-42-52; https://doaj.org/article/f72cf9f5b4344782b21a58fd3467576f

This is the first-time comparison of pneumonia course severity in two different ethnic groups of children in the conditions of the Far North with the account of acetylatory phenotype and intensity of free-adical oxidation. Genetic polymorphism on activity of N-cetyltransferase (N-АТ) enzyme is present in the majority of human populations as some have fast and others slow form of enzyme. According to this there are phenotypically distinguished people with slow and fast acetylatory phenotype, so-called slow and fast acetylators (SА and FА). SА-сhildren are to a greater degree the subject to complications in the cases of infectious diseases and do not easily response to therapies. The purpose of our research was to estimate the value of acetylatory phenotype of a child during the development of an acute respiratory infection complicated by pneumonia in both populations of children of Sakha Republic (native population – Yakuts and arrived population – Russians). There has been performed the examination of 112 children with acute respiratory infections complicated by pneumonia, and 49 practically healthy ones in the conditions of the Far North (Sakha). It is demonstrated that both Yakuts and Russians have to fight with pneumonia by free-radical oxidation activation (at the expense of “respiratory burst” reactions). It has been revealed that in the conditions of the Far North both hormones of stress, cortisol and somatotropic hormone work actively. The level of growth hormone was 2 times higher even in healthy Russian children to compare with Yakuts, (the level of growth hormone was 1,5 times higher among FА comparing with SА). The subpopulation structure of blood lymphocytes in SА-patients to a less degree depends on the intensity of free-radical oxidation to compare with FA-patients, especially in Yakuts population. Two independent parameters – speed of acetylation and free-radical oxidation intensity, regulating cell activation, synthesis of protection mediators and the level of hormones in blood, as well as ...