Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review.
Background Leprosy elimination primarily targets transmission of Mycobacterium leprae which is not restricted to patients' households. As interruption of transmission is imminent in many countries, a test to detect infected asymptomatic individuals who can perpetuate transmission is required. A...
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ftdoajarticles:oai:doaj.org/article:f72976ede2cd4c239adb0bd75f6fb491 2023-05-15T15:14:38+02:00 Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. Louise Pierneef Anouk van Hooij Anneke Taal Raisa Rumbaut Mauricio Lisboa Nobre Wim van Brakel Annemieke Geluk 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009667 https://doaj.org/article/f72976ede2cd4c239adb0bd75f6fb491 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009667 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009667 https://doaj.org/article/f72976ede2cd4c239adb0bd75f6fb491 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009667 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009667 2022-12-31T13:55:47Z Background Leprosy elimination primarily targets transmission of Mycobacterium leprae which is not restricted to patients' households. As interruption of transmission is imminent in many countries, a test to detect infected asymptomatic individuals who can perpetuate transmission is required. Antibodies directed against M. leprae antigens are indicative of M. leprae infection but cannot discriminate between active and past infection. Seroprevalence in young children, however, reflects recent M. leprae infection and may thus be used to monitor transmission in an area. Therefore, this literature review aimed to evaluate what has been reported on serological tests measuring anti-M. leprae antibodies in children without leprosy below the age of 15 in leprosy-endemic areas. Methods and findings A literature search was performed in the databases Pubmed, Infolep, Web of Science and The Virtual Health Library. From the 724 articles identified through the search criteria, 28 full-text articles fulfilled all inclusion criteria. Two additional papers were identified through snowballing, resulting in a total of 30 articles reporting data from ten countries. All serological tests measured antibodies against phenolic glycolipid-I or synthetic derivatives thereof, either quantitatively (ELISA or UCP-LFA) or qualitatively (ML-flow or NDO-LID rapid test). The median seroprevalence in children in endemic areas was 14.9% and was stable over time if disease incidence remained unchanged. Importantly, seroprevalence decreased with age, indicating that children are a suitable group for sensitive assessment of recent M. leprae infection. However, direct comparison between areas, solely based on the data reported in these studies, was impeded by the use of different tests and variable cut-off levels. Conclusions Quantitative anti-PGL-I serology in young children holds promise as a screening test to assess M. leprae infection and may be applied as a proxy for transmission and thereby as a means to monitor the effect of (prophylactic) ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 8 e0009667 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Louise Pierneef Anouk van Hooij Anneke Taal Raisa Rumbaut Mauricio Lisboa Nobre Wim van Brakel Annemieke Geluk Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Leprosy elimination primarily targets transmission of Mycobacterium leprae which is not restricted to patients' households. As interruption of transmission is imminent in many countries, a test to detect infected asymptomatic individuals who can perpetuate transmission is required. Antibodies directed against M. leprae antigens are indicative of M. leprae infection but cannot discriminate between active and past infection. Seroprevalence in young children, however, reflects recent M. leprae infection and may thus be used to monitor transmission in an area. Therefore, this literature review aimed to evaluate what has been reported on serological tests measuring anti-M. leprae antibodies in children without leprosy below the age of 15 in leprosy-endemic areas. Methods and findings A literature search was performed in the databases Pubmed, Infolep, Web of Science and The Virtual Health Library. From the 724 articles identified through the search criteria, 28 full-text articles fulfilled all inclusion criteria. Two additional papers were identified through snowballing, resulting in a total of 30 articles reporting data from ten countries. All serological tests measured antibodies against phenolic glycolipid-I or synthetic derivatives thereof, either quantitatively (ELISA or UCP-LFA) or qualitatively (ML-flow or NDO-LID rapid test). The median seroprevalence in children in endemic areas was 14.9% and was stable over time if disease incidence remained unchanged. Importantly, seroprevalence decreased with age, indicating that children are a suitable group for sensitive assessment of recent M. leprae infection. However, direct comparison between areas, solely based on the data reported in these studies, was impeded by the use of different tests and variable cut-off levels. Conclusions Quantitative anti-PGL-I serology in young children holds promise as a screening test to assess M. leprae infection and may be applied as a proxy for transmission and thereby as a means to monitor the effect of (prophylactic) ... |
format |
Article in Journal/Newspaper |
author |
Louise Pierneef Anouk van Hooij Anneke Taal Raisa Rumbaut Mauricio Lisboa Nobre Wim van Brakel Annemieke Geluk |
author_facet |
Louise Pierneef Anouk van Hooij Anneke Taal Raisa Rumbaut Mauricio Lisboa Nobre Wim van Brakel Annemieke Geluk |
author_sort |
Louise Pierneef |
title |
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
title_short |
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
title_full |
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
title_fullStr |
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
title_full_unstemmed |
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review. |
title_sort |
detection of anti-m. leprae antibodies in children in leprosy-endemic areas: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009667 https://doaj.org/article/f72976ede2cd4c239adb0bd75f6fb491 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009667 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009667 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009667 https://doaj.org/article/f72976ede2cd4c239adb0bd75f6fb491 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009667 |
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PLOS Neglected Tropical Diseases |
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15 |
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8 |
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e0009667 |
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