Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study.
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pone.0241373 https://doaj.org/article/f7037f08eaef4666aacaf161d4481e5e |
id |
ftdoajarticles:oai:doaj.org/article:f7037f08eaef4666aacaf161d4481e5e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f7037f08eaef4666aacaf161d4481e5e 2023-05-15T18:34:41+02:00 Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. Lars B Hindenes Asta K Håberg Liv Hege Johnsen Ellisiv B Mathiesen David Robben Torgil R Vangberg 2020-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0241373 https://doaj.org/article/f7037f08eaef4666aacaf161d4481e5e EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0241373 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0241373 https://doaj.org/article/f7037f08eaef4666aacaf161d4481e5e PLoS ONE, Vol 15, Iss 11, p e0241373 (2020) Medicine R Science Q article 2020 ftdoajarticles https://doi.org/10.1371/journal.pone.0241373 2022-12-31T13:00:28Z The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40-87 years), and independent and conditional frequencies of the CoW's artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø Willis ENVELOPE(159.450,159.450,-79.367,-79.367) PLOS ONE 15 11 e0241373 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Lars B Hindenes Asta K Håberg Liv Hege Johnsen Ellisiv B Mathiesen David Robben Torgil R Vangberg Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
topic_facet |
Medicine R Science Q |
description |
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40-87 years), and independent and conditional frequencies of the CoW's artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. |
format |
Article in Journal/Newspaper |
author |
Lars B Hindenes Asta K Håberg Liv Hege Johnsen Ellisiv B Mathiesen David Robben Torgil R Vangberg |
author_facet |
Lars B Hindenes Asta K Håberg Liv Hege Johnsen Ellisiv B Mathiesen David Robben Torgil R Vangberg |
author_sort |
Lars B Hindenes |
title |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
title_short |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
title_full |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
title_fullStr |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
title_full_unstemmed |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study. |
title_sort |
variations in the circle of willis in a large population sample using 3d tof angiography: the tromsø study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pone.0241373 https://doaj.org/article/f7037f08eaef4666aacaf161d4481e5e |
long_lat |
ENVELOPE(159.450,159.450,-79.367,-79.367) |
geographic |
Tromsø Willis |
geographic_facet |
Tromsø Willis |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS ONE, Vol 15, Iss 11, p e0241373 (2020) |
op_relation |
https://doi.org/10.1371/journal.pone.0241373 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0241373 https://doaj.org/article/f7037f08eaef4666aacaf161d4481e5e |
op_doi |
https://doi.org/10.1371/journal.pone.0241373 |
container_title |
PLOS ONE |
container_volume |
15 |
container_issue |
11 |
container_start_page |
e0241373 |
_version_ |
1766219538531090432 |