Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium
Objective: To investigate the adverse effect of exposure to acetylsalicylic acid (ASA), diazinon (DIA) and their combination on oxidant/antioxidant status in rat erythrocytes and the ameliorating role of selenium (Se). Methods: Rats were oral administered ASA at the maximum administration dose (1 35...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:f6eb131a1b474933b332e72b4a9e22f0 2023-05-15T15:13:30+02:00 Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium Abdel-Tawab Halim Mossa Tarek Mohamed Heikal Samia Mostafa Mohamed Mohafrash 2014-07-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014APJTB-2013-0038 https://doaj.org/article/f6eb131a1b474933b332e72b4a9e22f0 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115300575 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014APJTB-2013-0038 https://doaj.org/article/f6eb131a1b474933b332e72b4a9e22f0 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S2, Pp S603-S609 (2014) Acetylsalicylic acid Diazinon Erythrocytes Oxidative stress Lipid peroxidation Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014APJTB-2013-0038 2022-12-31T14:04:31Z Objective: To investigate the adverse effect of exposure to acetylsalicylic acid (ASA), diazinon (DIA) and their combination on oxidant/antioxidant status in rat erythrocytes and the ameliorating role of selenium (Se). Methods: Rats were oral administered ASA at the maximum administration dose (1 350 mg/personal/d=2.5 mg/kg body weight/d), DIA at a dose of 20 mg/kg body weight/d and Se at a dose of 200 µg/kg body weight/d and their combinations for 28 consecutive d. Results: Administration of DIA, ASA and ASA+DIA lead to a significant increment (P≤0.05) in lipid peroxidation as evidenced by the increase in erythrocytes MDA levels by 61.8%, 20.79% and 105.62%, respectively. Co-administration of Se to treated rats modulated the augmentation of MDA levels. Administration of DIA, ASA and ASA+DIA lead to significant decreases (P≤0.05) in the activities of catalase, superoxide dismutase and glutathione peroxidase enzymes when compared to the control group. The most influence and decreases in the activities of the aforementioned enzymes were observed in the treatments of ASA+DIA by 30.53%, 43.42% and 48.31%, respectively. However, co-administration of Se mitigated the significant decreases of superoxide dismutase, catalase and glutathione peroxidase activities to by 14.47%, 15, 36% and 12.29%. Conclusions: It can be concluded that DIA and ASA induced oxidative stress and lipid peroxidation in rat erythrocytes. The results reveal the pronounced ameliorating effect of Se in DIA and ASA intoxicated rats. It is supposed that antioxidant supplementation may be beneficial for the people using ASA for longer periods and exposure to pesticides. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 S603 S609 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Acetylsalicylic acid Diazinon Erythrocytes Oxidative stress Lipid peroxidation Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Acetylsalicylic acid Diazinon Erythrocytes Oxidative stress Lipid peroxidation Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Abdel-Tawab Halim Mossa Tarek Mohamed Heikal Samia Mostafa Mohamed Mohafrash Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
topic_facet |
Acetylsalicylic acid Diazinon Erythrocytes Oxidative stress Lipid peroxidation Rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the adverse effect of exposure to acetylsalicylic acid (ASA), diazinon (DIA) and their combination on oxidant/antioxidant status in rat erythrocytes and the ameliorating role of selenium (Se). Methods: Rats were oral administered ASA at the maximum administration dose (1 350 mg/personal/d=2.5 mg/kg body weight/d), DIA at a dose of 20 mg/kg body weight/d and Se at a dose of 200 µg/kg body weight/d and their combinations for 28 consecutive d. Results: Administration of DIA, ASA and ASA+DIA lead to a significant increment (P≤0.05) in lipid peroxidation as evidenced by the increase in erythrocytes MDA levels by 61.8%, 20.79% and 105.62%, respectively. Co-administration of Se to treated rats modulated the augmentation of MDA levels. Administration of DIA, ASA and ASA+DIA lead to significant decreases (P≤0.05) in the activities of catalase, superoxide dismutase and glutathione peroxidase enzymes when compared to the control group. The most influence and decreases in the activities of the aforementioned enzymes were observed in the treatments of ASA+DIA by 30.53%, 43.42% and 48.31%, respectively. However, co-administration of Se mitigated the significant decreases of superoxide dismutase, catalase and glutathione peroxidase activities to by 14.47%, 15, 36% and 12.29%. Conclusions: It can be concluded that DIA and ASA induced oxidative stress and lipid peroxidation in rat erythrocytes. The results reveal the pronounced ameliorating effect of Se in DIA and ASA intoxicated rats. It is supposed that antioxidant supplementation may be beneficial for the people using ASA for longer periods and exposure to pesticides. |
format |
Article in Journal/Newspaper |
author |
Abdel-Tawab Halim Mossa Tarek Mohamed Heikal Samia Mostafa Mohamed Mohafrash |
author_facet |
Abdel-Tawab Halim Mossa Tarek Mohamed Heikal Samia Mostafa Mohamed Mohafrash |
author_sort |
Abdel-Tawab Halim Mossa |
title |
Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
title_short |
Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
title_full |
Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
title_fullStr |
Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
title_full_unstemmed |
Lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
title_sort |
lipid peroxidation and oxidative stress in rat erythrocytes induced by aspirin and diazinon: the protective role of selenium |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014APJTB-2013-0038 https://doaj.org/article/f6eb131a1b474933b332e72b4a9e22f0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S2, Pp S603-S609 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115300575 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014APJTB-2013-0038 https://doaj.org/article/f6eb131a1b474933b332e72b4a9e22f0 |
op_doi |
https://doi.org/10.12980/APJTB.4.2014APJTB-2013-0038 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_start_page |
S603 |
op_container_end_page |
S609 |
_version_ |
1766344052789215232 |