Identification of human semiochemicals attractive to the major vectors of onchocerciasis.
Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the devel...
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ftdoajarticles:oai:doaj.org/article:f6ea5d56bf1b4239aed42294123350a9 2023-05-15T15:12:26+02:00 Identification of human semiochemicals attractive to the major vectors of onchocerciasis. Ryan M Young Nathan D Burkett-Cadena Tommy W McGaha Mario A Rodriguez-Perez Laurent D Toé Monsuru A Adeleke Moussa Sanfo Traore Soungalo Charles R Katholi Raymond Noblet Henry Fadamiro Jose L Torres-Estrada Mario C Salinas-Carmona Bill Baker Thomas R Unnasch Eddie W Cupp 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003450 https://doaj.org/article/f6ea5d56bf1b4239aed42294123350a9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4287528?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003450 https://doaj.org/article/f6ea5d56bf1b4239aed42294123350a9 PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3450 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003450 2022-12-31T12:14:15Z Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the development of traps that have the potential for replacing humans for surveillance of O. volvulus in the vector population. However, the key chemical components of human odor that are attractive to vector black flies have not been identified.Human sweat compounds were analyzed using GC-MS analysis and compounds common to three individuals identified. These common compounds, with others previously identified as attractive to other hematophagous arthropods were evaluated for their ability to stimulate and attract the major onchocerciasis vectors in Africa (Simulium damnosum sensu lato) and Latin America (Simulium ochraceum s. l.) using electroantennography and a Y tube binary choice assay. Medium chain length carboxylic acids and aldehydes were neurostimulatory for S. damnosum s.l. while S. ochraceum s.l. was stimulated by short chain aliphatic alcohols and aldehydes. Both species were attracted to ammonium bicarbonate and acetophenone. The compounds were shown to be attractive to the relevant vector species in field studies, when incorporated into a formulation that permitted a continuous release of the compound over time and used in concert with previously developed trap platforms.The identification of compounds attractive to the major vectors of O. volvulus will permit the development of optimized traps. Such traps may replace the use of human vector collectors for monitoring the effectiveness of onchocerciasis elimination programs and could find use as a contributing component in an integrated vector control/drug program aimed at eliminating river blindness in Africa. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 9 1 e3450 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ryan M Young Nathan D Burkett-Cadena Tommy W McGaha Mario A Rodriguez-Perez Laurent D Toé Monsuru A Adeleke Moussa Sanfo Traore Soungalo Charles R Katholi Raymond Noblet Henry Fadamiro Jose L Torres-Estrada Mario C Salinas-Carmona Bill Baker Thomas R Unnasch Eddie W Cupp Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the development of traps that have the potential for replacing humans for surveillance of O. volvulus in the vector population. However, the key chemical components of human odor that are attractive to vector black flies have not been identified.Human sweat compounds were analyzed using GC-MS analysis and compounds common to three individuals identified. These common compounds, with others previously identified as attractive to other hematophagous arthropods were evaluated for their ability to stimulate and attract the major onchocerciasis vectors in Africa (Simulium damnosum sensu lato) and Latin America (Simulium ochraceum s. l.) using electroantennography and a Y tube binary choice assay. Medium chain length carboxylic acids and aldehydes were neurostimulatory for S. damnosum s.l. while S. ochraceum s.l. was stimulated by short chain aliphatic alcohols and aldehydes. Both species were attracted to ammonium bicarbonate and acetophenone. The compounds were shown to be attractive to the relevant vector species in field studies, when incorporated into a formulation that permitted a continuous release of the compound over time and used in concert with previously developed trap platforms.The identification of compounds attractive to the major vectors of O. volvulus will permit the development of optimized traps. Such traps may replace the use of human vector collectors for monitoring the effectiveness of onchocerciasis elimination programs and could find use as a contributing component in an integrated vector control/drug program aimed at eliminating river blindness in Africa. |
format |
Article in Journal/Newspaper |
author |
Ryan M Young Nathan D Burkett-Cadena Tommy W McGaha Mario A Rodriguez-Perez Laurent D Toé Monsuru A Adeleke Moussa Sanfo Traore Soungalo Charles R Katholi Raymond Noblet Henry Fadamiro Jose L Torres-Estrada Mario C Salinas-Carmona Bill Baker Thomas R Unnasch Eddie W Cupp |
author_facet |
Ryan M Young Nathan D Burkett-Cadena Tommy W McGaha Mario A Rodriguez-Perez Laurent D Toé Monsuru A Adeleke Moussa Sanfo Traore Soungalo Charles R Katholi Raymond Noblet Henry Fadamiro Jose L Torres-Estrada Mario C Salinas-Carmona Bill Baker Thomas R Unnasch Eddie W Cupp |
author_sort |
Ryan M Young |
title |
Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
title_short |
Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
title_full |
Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
title_fullStr |
Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
title_full_unstemmed |
Identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
title_sort |
identification of human semiochemicals attractive to the major vectors of onchocerciasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003450 https://doaj.org/article/f6ea5d56bf1b4239aed42294123350a9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3450 (2015) |
op_relation |
http://europepmc.org/articles/PMC4287528?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003450 https://doaj.org/article/f6ea5d56bf1b4239aed42294123350a9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003450 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
9 |
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1 |
container_start_page |
e3450 |
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1766343112933769216 |