Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats
Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from...
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Swedish Nutrition Foundation
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ftdoajarticles:oai:doaj.org/article:f6c7551947054d60b1849a9282cca923 2023-05-15T15:27:05+02:00 Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen 2022-10-01T00:00:00Z https://doi.org/10.29219/fnr.v66.8708 https://doaj.org/article/f6c7551947054d60b1849a9282cca923 EN eng Swedish Nutrition Foundation https://foodandnutritionresearch.net/index.php/fnr/article/view/8708/14911 https://doaj.org/toc/1654-661X 1654-661X doi:10.29219/fnr.v66.8708 https://doaj.org/article/f6c7551947054d60b1849a9282cca923 Food & Nutrition Research, Vol 66, Pp 1-11 (2022) fish proteins fish residuals blood pressure hypertension kidney obesity Nutrition. Foods and food supply TX341-641 article 2022 ftdoajarticles https://doi.org/10.29219/fnr.v66.8708 2022-12-30T23:23:27Z Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from Atlantic cod (Gadus morhua) filleting on the development of high blood pressure in obese Zucker fa/fa rats, which spontaneously develop hypertension and proteinuria. The secondary objectives were to investigate any changes in kidney morphology, kidney function and organ damage, and to determine the potential inhibition of cod residuals on renin and angiotensin-converting enzyme (ACE) activities in vitro. Methods: Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically. Results: The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups. Conclusion: A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles Food & Nutrition Research 66 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
fish proteins fish residuals blood pressure hypertension kidney obesity Nutrition. Foods and food supply TX341-641 |
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fish proteins fish residuals blood pressure hypertension kidney obesity Nutrition. Foods and food supply TX341-641 Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
topic_facet |
fish proteins fish residuals blood pressure hypertension kidney obesity Nutrition. Foods and food supply TX341-641 |
description |
Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from Atlantic cod (Gadus morhua) filleting on the development of high blood pressure in obese Zucker fa/fa rats, which spontaneously develop hypertension and proteinuria. The secondary objectives were to investigate any changes in kidney morphology, kidney function and organ damage, and to determine the potential inhibition of cod residuals on renin and angiotensin-converting enzyme (ACE) activities in vitro. Methods: Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically. Results: The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups. Conclusion: A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage. |
format |
Article in Journal/Newspaper |
author |
Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen |
author_facet |
Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen |
author_sort |
Iselin Vildmyren |
title |
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
title_short |
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
title_full |
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
title_fullStr |
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
title_full_unstemmed |
Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
title_sort |
intake of residuals from atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese zucker fa/fa rats |
publisher |
Swedish Nutrition Foundation |
publishDate |
2022 |
url |
https://doi.org/10.29219/fnr.v66.8708 https://doaj.org/article/f6c7551947054d60b1849a9282cca923 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
Food & Nutrition Research, Vol 66, Pp 1-11 (2022) |
op_relation |
https://foodandnutritionresearch.net/index.php/fnr/article/view/8708/14911 https://doaj.org/toc/1654-661X 1654-661X doi:10.29219/fnr.v66.8708 https://doaj.org/article/f6c7551947054d60b1849a9282cca923 |
op_doi |
https://doi.org/10.29219/fnr.v66.8708 |
container_title |
Food & Nutrition Research |
container_volume |
66 |
_version_ |
1766357541072142336 |