Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
Abstract Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hosp...
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ftdoajarticles:oai:doaj.org/article:f67ac36c49e04c49b60a8fc07da299fc 2023-05-15T15:12:32+02:00 Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis Kager Piet Berkley James A Mturi Florence N Talbert Alison W Mwaniki Michael K Marsh Kevin Newton Charles R 2010-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-313 https://doaj.org/article/f67ac36c49e04c49b60a8fc07da299fc EN eng BMC http://www.malariajournal.com/content/9/1/313 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-313 1475-2875 https://doaj.org/article/f67ac36c49e04c49b60a8fc07da299fc Malaria Journal, Vol 9, Iss 1, p 313 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-313 2022-12-31T10:21:30Z Abstract Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From 1 st January 2002 to 31 st December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl (χ 2 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kager Piet Berkley James A Mturi Florence N Talbert Alison W Mwaniki Michael K Marsh Kevin Newton Charles R Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From 1 st January 2002 to 31 st December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl (χ 2 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. |
format |
Article in Journal/Newspaper |
author |
Kager Piet Berkley James A Mturi Florence N Talbert Alison W Mwaniki Michael K Marsh Kevin Newton Charles R |
author_facet |
Kager Piet Berkley James A Mturi Florence N Talbert Alison W Mwaniki Michael K Marsh Kevin Newton Charles R |
author_sort |
Kager Piet |
title |
Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
title_short |
Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
title_full |
Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
title_fullStr |
Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
title_full_unstemmed |
Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis |
title_sort |
congenital and neonatal malaria in a rural kenyan district hospital: an eight-year analysis |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-313 https://doaj.org/article/f67ac36c49e04c49b60a8fc07da299fc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 313 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/313 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-313 1475-2875 https://doaj.org/article/f67ac36c49e04c49b60a8fc07da299fc |
op_doi |
https://doi.org/10.1186/1475-2875-9-313 |
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Malaria Journal |
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9 |
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