Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections
Abstract Background During intra-erythrocytic replication Plasmodium falciparum escapes the human host immune system by switching expression of variant surface antigens (VSA). Piecemeal acquisition of variant specific antibody responses to these antigens as a result of exposure to multiple re-infect...
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ftdoajarticles:oai:doaj.org/article:f65f1a33da41443db4bb55f6d91f445a 2023-05-15T15:07:47+02:00 Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections Elise Schieck E. Jane Poole Anja Rippert Judy Peshu Philip Sasi Steffen Borrmann Peter C. Bull 2017-11-01T00:00:00Z https://doi.org/10.1186/s12936-017-2097-0 https://doaj.org/article/f65f1a33da41443db4bb55f6d91f445a EN eng BMC http://link.springer.com/article/10.1186/s12936-017-2097-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2097-0 1475-2875 https://doaj.org/article/f65f1a33da41443db4bb55f6d91f445a Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017) Plasmodium falciparum Malaria Recurrent infection Recrudescent infection Antibody aquisition Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-2097-0 2022-12-31T00:20:25Z Abstract Background During intra-erythrocytic replication Plasmodium falciparum escapes the human host immune system by switching expression of variant surface antigens (VSA). Piecemeal acquisition of variant specific antibody responses to these antigens as a result of exposure to multiple re-infections has been proposed to play a role in acquisition of naturally acquired immunity. Methods Immunofluorescence was used to explore the dynamics of anti-VSA IgG responses generated by children to (i) primary malaria episodes and (ii) recurrent P. falciparum infections. Results Consistent with previous studies on anti-VSA responses, sera from each child taken at the time of recovery from their respective primary infection tended to recognize their own secondary parasites poorly. Additionally, compared to patients with reinfections by parasites of new merozoite surface protein 2 (MSP2) genotypes, baseline sera sampled from patients with persistent infections (recrudescence) tended to have higher recognition of heterologous parasites. This is consistent with the prediction that anti-VSA IgG responses may play a role in promoting chronic asymptomatic infections. Conclusions This pilot study validates the utility of recurrent natural malaria infections as a functional readout for examining the incremental acquisition of immunity to malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Plasmodium falciparum Malaria Recurrent infection Recrudescent infection Antibody aquisition Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Plasmodium falciparum Malaria Recurrent infection Recrudescent infection Antibody aquisition Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Elise Schieck E. Jane Poole Anja Rippert Judy Peshu Philip Sasi Steffen Borrmann Peter C. Bull Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
topic_facet |
Plasmodium falciparum Malaria Recurrent infection Recrudescent infection Antibody aquisition Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background During intra-erythrocytic replication Plasmodium falciparum escapes the human host immune system by switching expression of variant surface antigens (VSA). Piecemeal acquisition of variant specific antibody responses to these antigens as a result of exposure to multiple re-infections has been proposed to play a role in acquisition of naturally acquired immunity. Methods Immunofluorescence was used to explore the dynamics of anti-VSA IgG responses generated by children to (i) primary malaria episodes and (ii) recurrent P. falciparum infections. Results Consistent with previous studies on anti-VSA responses, sera from each child taken at the time of recovery from their respective primary infection tended to recognize their own secondary parasites poorly. Additionally, compared to patients with reinfections by parasites of new merozoite surface protein 2 (MSP2) genotypes, baseline sera sampled from patients with persistent infections (recrudescence) tended to have higher recognition of heterologous parasites. This is consistent with the prediction that anti-VSA IgG responses may play a role in promoting chronic asymptomatic infections. Conclusions This pilot study validates the utility of recurrent natural malaria infections as a functional readout for examining the incremental acquisition of immunity to malaria. |
format |
Article in Journal/Newspaper |
author |
Elise Schieck E. Jane Poole Anja Rippert Judy Peshu Philip Sasi Steffen Borrmann Peter C. Bull |
author_facet |
Elise Schieck E. Jane Poole Anja Rippert Judy Peshu Philip Sasi Steffen Borrmann Peter C. Bull |
author_sort |
Elise Schieck |
title |
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
title_short |
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
title_full |
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
title_fullStr |
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
title_full_unstemmed |
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
title_sort |
plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-2097-0 https://doaj.org/article/f65f1a33da41443db4bb55f6d91f445a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-2097-0 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-2097-0 1475-2875 https://doaj.org/article/f65f1a33da41443db4bb55f6d91f445a |
op_doi |
https://doi.org/10.1186/s12936-017-2097-0 |
container_title |
Malaria Journal |
container_volume |
16 |
container_issue |
1 |
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1766339206906380288 |