SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis
Abstract Background SARS-CoV-2 seroepidemiological studies are used to guide public health decision making and to prepare for emerging infectious diseases. Disease occurrence estimates are limited in the Philippines, the country with the highest reported number of coronavirus disease-related deaths...
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Online Access: | https://doi.org/10.1186/s41182-022-00468-7 https://doaj.org/article/f5ea2d669d0b4d048ac34933c8c0d9f3 |
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ftdoajarticles:oai:doaj.org/article:f5ea2d669d0b4d048ac34933c8c0d9f3 2023-05-15T15:16:06+02:00 SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis Greco Mark B. Malijan Tansy Edwards Kristal An Agrupis Shuichi Suzuki Annavi Marie G. Villanueva Ana Ria Sayo Ferdinand De Guzman Alexis Q. Dimapilis Rontgene M. Solante Elizabeth O. Telan Dorcas V. Umipig Kenji Ota Fumitaka Nishimura Katsunori Yanagihara Mary Jane Salazar Edmundo B. Lopez Koya Ariyoshi Chris Smith 2022-10-01T00:00:00Z https://doi.org/10.1186/s41182-022-00468-7 https://doaj.org/article/f5ea2d669d0b4d048ac34933c8c0d9f3 EN eng BMC https://doi.org/10.1186/s41182-022-00468-7 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00468-7 1349-4147 https://doaj.org/article/f5ea2d669d0b4d048ac34933c8c0d9f3 Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-13 (2022) SARS-CoV-2 COVID-19 Seroepidemiological study Philippines Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1186/s41182-022-00468-7 2022-12-30T21:32:37Z Abstract Background SARS-CoV-2 seroepidemiological studies are used to guide public health decision making and to prepare for emerging infectious diseases. Disease occurrence estimates are limited in the Philippines, the country with the highest reported number of coronavirus disease-related deaths in the Western Pacific region. We aimed to estimate SARS-CoV-2 seroprevalence and infection rate among outpatient clinic attendees in Metro Manila prior to the implementation of the national coronavirus disease vaccination program. Methods We conducted repeated cross-sectional surveys at the animal bite clinic in San Lazaro Hospital, Manila, the Philippines across four periods, 3 months apart, between May 2020 and March 2021. Multivariable logistic regression was used to assess associations between different characteristics and infection status including seropositivity. Results In total 615 participants were enrolled, ranging from 115 to 174 per period. Seroprevalence quadrupled between the first (11.3%) and second (46.8%) periods and plateaued thereafter (third—46.0%, fourth—44.6%). Among seropositive participants, total antibody concentration was comparable throughout the first to third periods but declined between the third and fourth periods. Infection prevalence was comparable across enrollment periods (range 2.9–9.5%). Post-secondary education [aOR 0.42 (95% CI 0.26, 0.67)] was protective, and frontline work [aOR 1.81 (95% CI 1.18, 2.80)] was associated with increased odds of seropositivity. Frontline work status [aOR 2.27 (95% CI 1.10, 4.75)] and large household size [aOR 2.45 (95% CI 1.18, 5.49)] were associated with increased odds of infection. Conclusions The quadrupling of seroprevalence over 3 months between the first and second enrollment periods coincided with the high burden of infection in Metro Manila in early 2020. Our findings suggest a limit to the rise and potential decline of population-level SARS-CoV-2 infection-induced immunity without introduction of vaccines. These results may add to our ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific Tropical Medicine and Health 50 1 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
SARS-CoV-2 COVID-19 Seroepidemiological study Philippines Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
SARS-CoV-2 COVID-19 Seroepidemiological study Philippines Arctic medicine. Tropical medicine RC955-962 Greco Mark B. Malijan Tansy Edwards Kristal An Agrupis Shuichi Suzuki Annavi Marie G. Villanueva Ana Ria Sayo Ferdinand De Guzman Alexis Q. Dimapilis Rontgene M. Solante Elizabeth O. Telan Dorcas V. Umipig Kenji Ota Fumitaka Nishimura Katsunori Yanagihara Mary Jane Salazar Edmundo B. Lopez Koya Ariyoshi Chris Smith SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
topic_facet |
SARS-CoV-2 COVID-19 Seroepidemiological study Philippines Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background SARS-CoV-2 seroepidemiological studies are used to guide public health decision making and to prepare for emerging infectious diseases. Disease occurrence estimates are limited in the Philippines, the country with the highest reported number of coronavirus disease-related deaths in the Western Pacific region. We aimed to estimate SARS-CoV-2 seroprevalence and infection rate among outpatient clinic attendees in Metro Manila prior to the implementation of the national coronavirus disease vaccination program. Methods We conducted repeated cross-sectional surveys at the animal bite clinic in San Lazaro Hospital, Manila, the Philippines across four periods, 3 months apart, between May 2020 and March 2021. Multivariable logistic regression was used to assess associations between different characteristics and infection status including seropositivity. Results In total 615 participants were enrolled, ranging from 115 to 174 per period. Seroprevalence quadrupled between the first (11.3%) and second (46.8%) periods and plateaued thereafter (third—46.0%, fourth—44.6%). Among seropositive participants, total antibody concentration was comparable throughout the first to third periods but declined between the third and fourth periods. Infection prevalence was comparable across enrollment periods (range 2.9–9.5%). Post-secondary education [aOR 0.42 (95% CI 0.26, 0.67)] was protective, and frontline work [aOR 1.81 (95% CI 1.18, 2.80)] was associated with increased odds of seropositivity. Frontline work status [aOR 2.27 (95% CI 1.10, 4.75)] and large household size [aOR 2.45 (95% CI 1.18, 5.49)] were associated with increased odds of infection. Conclusions The quadrupling of seroprevalence over 3 months between the first and second enrollment periods coincided with the high burden of infection in Metro Manila in early 2020. Our findings suggest a limit to the rise and potential decline of population-level SARS-CoV-2 infection-induced immunity without introduction of vaccines. These results may add to our ... |
format |
Article in Journal/Newspaper |
author |
Greco Mark B. Malijan Tansy Edwards Kristal An Agrupis Shuichi Suzuki Annavi Marie G. Villanueva Ana Ria Sayo Ferdinand De Guzman Alexis Q. Dimapilis Rontgene M. Solante Elizabeth O. Telan Dorcas V. Umipig Kenji Ota Fumitaka Nishimura Katsunori Yanagihara Mary Jane Salazar Edmundo B. Lopez Koya Ariyoshi Chris Smith |
author_facet |
Greco Mark B. Malijan Tansy Edwards Kristal An Agrupis Shuichi Suzuki Annavi Marie G. Villanueva Ana Ria Sayo Ferdinand De Guzman Alexis Q. Dimapilis Rontgene M. Solante Elizabeth O. Telan Dorcas V. Umipig Kenji Ota Fumitaka Nishimura Katsunori Yanagihara Mary Jane Salazar Edmundo B. Lopez Koya Ariyoshi Chris Smith |
author_sort |
Greco Mark B. Malijan |
title |
SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
title_short |
SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
title_full |
SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
title_fullStr |
SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
title_full_unstemmed |
SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
title_sort |
sars-cov-2 seroprevalence and infection rate in manila, philippines prior to national vaccination program implementation: a repeated cross-sectional analysis |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s41182-022-00468-7 https://doaj.org/article/f5ea2d669d0b4d048ac34933c8c0d9f3 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-13 (2022) |
op_relation |
https://doi.org/10.1186/s41182-022-00468-7 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-022-00468-7 1349-4147 https://doaj.org/article/f5ea2d669d0b4d048ac34933c8c0d9f3 |
op_doi |
https://doi.org/10.1186/s41182-022-00468-7 |
container_title |
Tropical Medicine and Health |
container_volume |
50 |
container_issue |
1 |
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1766346411693047808 |