Zika virus infection and microcephaly: Evidence regarding geospatial associations.
BACKGROUND:Although the Zika virus (ZIKV) epidemic ceased to be a public health emergency by the end of 2016, studies to improve knowledge about this emerging disease are still needed, especially those investigating a causal relationship between ZIKV in pregnant women and microcephaly in neonates. H...
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ftdoajarticles:oai:doaj.org/article:f5dca4f3ce8444bbae1b785b769da1f4 2023-05-15T15:14:39+02:00 Zika virus infection and microcephaly: Evidence regarding geospatial associations. João Ricardo Nickenig Vissoci Thiago Augusto Hernandes Rocha Núbia Cristina da Silva Rejane Christine de Sousa Queiroz Erika Bárbara Abreu Fonseca Thomaz Pedro Vasconcelos Maia Amaral Adriana Lein Maria Dos Remédios Freitas Carvalho Branco José Aquino Zulimar Márita Ribeiro Rodrigues Antônio Augusto Moura da Silva Catherine Staton 2018-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006392 https://doaj.org/article/f5dca4f3ce8444bbae1b785b769da1f4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5937996?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006392 https://doaj.org/article/f5dca4f3ce8444bbae1b785b769da1f4 PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006392 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006392 2023-01-08T01:24:30Z BACKGROUND:Although the Zika virus (ZIKV) epidemic ceased to be a public health emergency by the end of 2016, studies to improve knowledge about this emerging disease are still needed, especially those investigating a causal relationship between ZIKV in pregnant women and microcephaly in neonates. However, there are still many challenges in describing the relationship between ZIKV and microcephaly. The few studies focusing on the epidemiological profile of ZIKV and its changes over time are largely limited to systematic reviews of case reports and dispersal mapping of ZIKV spread over time without quantitative methods to analyze patterns and their covariates. Since Brazil has been at the epicenter of the ZIKV epidemic, this study examines the geospatial association between ZIKV and microcephaly in Brazil. METHODS:Our study is categorized as a retrospective, ecological study based on secondary databases. Data were obtained from January to December 2016, from the following data sources: Brazilian System for Epidemiological Surveillance, Disease Notification System, System for Specialized Management Support, and Brazilian Institute of Geography and Statistics. Data were aggregated by municipality. Incidence rates were estimated per 100,000 inhabitants. Analyses consisted of mapping the aggregated incidence rates of ZIKV and microcephaly, followed by a Getis-Ord-Gi spatial cluster analysis and a Bivariate Local Moran's I analysis. RESULTS:The incidence of ZIKV cases is changing the virus's spatial pattern, shifting from Brazil's Northeast region to the Midwest and North regions. The number of municipalities in clusters of microcephaly incidence is also shifting from the Northeast region to the Midwest and North, after a time lag is considered. Our findings suggest an increase in microcephaly incidence in the Midwest and North regions, associated with high levels of ZIKV infection months before. CONCLUSION:The greatest burden of microcephaly shifted from the Northeast to other Brazilian regions at the beginning of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 4 e0006392 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 João Ricardo Nickenig Vissoci Thiago Augusto Hernandes Rocha Núbia Cristina da Silva Rejane Christine de Sousa Queiroz Erika Bárbara Abreu Fonseca Thomaz Pedro Vasconcelos Maia Amaral Adriana Lein Maria Dos Remédios Freitas Carvalho Branco José Aquino Zulimar Márita Ribeiro Rodrigues Antônio Augusto Moura da Silva Catherine Staton Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Although the Zika virus (ZIKV) epidemic ceased to be a public health emergency by the end of 2016, studies to improve knowledge about this emerging disease are still needed, especially those investigating a causal relationship between ZIKV in pregnant women and microcephaly in neonates. However, there are still many challenges in describing the relationship between ZIKV and microcephaly. The few studies focusing on the epidemiological profile of ZIKV and its changes over time are largely limited to systematic reviews of case reports and dispersal mapping of ZIKV spread over time without quantitative methods to analyze patterns and their covariates. Since Brazil has been at the epicenter of the ZIKV epidemic, this study examines the geospatial association between ZIKV and microcephaly in Brazil. METHODS:Our study is categorized as a retrospective, ecological study based on secondary databases. Data were obtained from January to December 2016, from the following data sources: Brazilian System for Epidemiological Surveillance, Disease Notification System, System for Specialized Management Support, and Brazilian Institute of Geography and Statistics. Data were aggregated by municipality. Incidence rates were estimated per 100,000 inhabitants. Analyses consisted of mapping the aggregated incidence rates of ZIKV and microcephaly, followed by a Getis-Ord-Gi spatial cluster analysis and a Bivariate Local Moran's I analysis. RESULTS:The incidence of ZIKV cases is changing the virus's spatial pattern, shifting from Brazil's Northeast region to the Midwest and North regions. The number of municipalities in clusters of microcephaly incidence is also shifting from the Northeast region to the Midwest and North, after a time lag is considered. Our findings suggest an increase in microcephaly incidence in the Midwest and North regions, associated with high levels of ZIKV infection months before. CONCLUSION:The greatest burden of microcephaly shifted from the Northeast to other Brazilian regions at the beginning of ... |
format |
Article in Journal/Newspaper |
author |
João Ricardo Nickenig Vissoci Thiago Augusto Hernandes Rocha Núbia Cristina da Silva Rejane Christine de Sousa Queiroz Erika Bárbara Abreu Fonseca Thomaz Pedro Vasconcelos Maia Amaral Adriana Lein Maria Dos Remédios Freitas Carvalho Branco José Aquino Zulimar Márita Ribeiro Rodrigues Antônio Augusto Moura da Silva Catherine Staton |
author_facet |
João Ricardo Nickenig Vissoci Thiago Augusto Hernandes Rocha Núbia Cristina da Silva Rejane Christine de Sousa Queiroz Erika Bárbara Abreu Fonseca Thomaz Pedro Vasconcelos Maia Amaral Adriana Lein Maria Dos Remédios Freitas Carvalho Branco José Aquino Zulimar Márita Ribeiro Rodrigues Antônio Augusto Moura da Silva Catherine Staton |
author_sort |
João Ricardo Nickenig Vissoci |
title |
Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
title_short |
Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
title_full |
Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
title_fullStr |
Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
title_full_unstemmed |
Zika virus infection and microcephaly: Evidence regarding geospatial associations. |
title_sort |
zika virus infection and microcephaly: evidence regarding geospatial associations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006392 https://doaj.org/article/f5dca4f3ce8444bbae1b785b769da1f4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006392 (2018) |
op_relation |
http://europepmc.org/articles/PMC5937996?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006392 https://doaj.org/article/f5dca4f3ce8444bbae1b785b769da1f4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006392 |
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PLOS Neglected Tropical Diseases |
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12 |
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4 |
container_start_page |
e0006392 |
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