Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice
Single doses of praziquantel were administered by oral route, at various time intervals, following the experimental infection of mice with Hymenolepis nana eggs (2000 per animal), to investigate the drug action against different development stages of the parasite. It was shown that either 25 or 50 m...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1984
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Online Access: | https://doi.org/10.1590/S0036-46651984000600008 https://doaj.org/article/f5d8cb2aa31c4e8fabcdddc2c3e452b4 |
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ftdoajarticles:oai:doaj.org/article:f5d8cb2aa31c4e8fabcdddc2c3e452b4 2024-09-09T19:25:52+00:00 Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice Rubens Campos M. C. R. V. Bressan M. G. B. F. Evangelista 1984-12-01T00:00:00Z https://doi.org/10.1590/S0036-46651984000600008 https://doaj.org/article/f5d8cb2aa31c4e8fabcdddc2c3e452b4 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651984000600008&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651984000600008 https://doaj.org/article/f5d8cb2aa31c4e8fabcdddc2c3e452b4 Revista do Instituto de Medicina Tropical de São Paulo, Vol 26, Iss 6, Pp 334-340 (1984) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1984 ftdoajarticles https://doi.org/10.1590/S0036-46651984000600008 2024-08-05T17:49:31Z Single doses of praziquantel were administered by oral route, at various time intervals, following the experimental infection of mice with Hymenolepis nana eggs (2000 per animal), to investigate the drug action against different development stages of the parasite. It was shown that either 25 or 50 mg/kg given on the 4th day after inoculation had just a partial effect against the cysticercoids. Moreover, 25 mg/kg given on the 7th day was not able to kill all juvenile forms as well. However, this dose administered on the 10th day, when the parasites had reached maturity taut oviposition was not yet initiated was 100% efficacious. The same degree of efficacy was achieved with the administration of 25 mg/kg on the 14th day when the fully mature worms already lay eggs. These animal findings indicate that in the treatment of human hymenolepiasis praziquantel, 25 mg/kg, should be taken twice, 10 days apart, so that the second dose kills the larval and juvenile forms which have survived the first one. This should be particularly recommended for treating H. nana infection in close communities. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 26 6 334 340 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Rubens Campos M. C. R. V. Bressan M. G. B. F. Evangelista Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Single doses of praziquantel were administered by oral route, at various time intervals, following the experimental infection of mice with Hymenolepis nana eggs (2000 per animal), to investigate the drug action against different development stages of the parasite. It was shown that either 25 or 50 mg/kg given on the 4th day after inoculation had just a partial effect against the cysticercoids. Moreover, 25 mg/kg given on the 7th day was not able to kill all juvenile forms as well. However, this dose administered on the 10th day, when the parasites had reached maturity taut oviposition was not yet initiated was 100% efficacious. The same degree of efficacy was achieved with the administration of 25 mg/kg on the 14th day when the fully mature worms already lay eggs. These animal findings indicate that in the treatment of human hymenolepiasis praziquantel, 25 mg/kg, should be taken twice, 10 days apart, so that the second dose kills the larval and juvenile forms which have survived the first one. This should be particularly recommended for treating H. nana infection in close communities. |
format |
Article in Journal/Newspaper |
author |
Rubens Campos M. C. R. V. Bressan M. G. B. F. Evangelista |
author_facet |
Rubens Campos M. C. R. V. Bressan M. G. B. F. Evangelista |
author_sort |
Rubens Campos |
title |
Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
title_short |
Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
title_full |
Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
title_fullStr |
Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
title_full_unstemmed |
Activity of praziquantel against Hymenolepis nana, at different development stages, in experimentally infected mice |
title_sort |
activity of praziquantel against hymenolepis nana, at different development stages, in experimentally infected mice |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1984 |
url |
https://doi.org/10.1590/S0036-46651984000600008 https://doaj.org/article/f5d8cb2aa31c4e8fabcdddc2c3e452b4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 26, Iss 6, Pp 334-340 (1984) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651984000600008&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651984000600008 https://doaj.org/article/f5d8cb2aa31c4e8fabcdddc2c3e452b4 |
op_doi |
https://doi.org/10.1590/S0036-46651984000600008 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
26 |
container_issue |
6 |
container_start_page |
334 |
op_container_end_page |
340 |
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1809895583002918912 |