Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study.
During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the highest rates reported in young children. Immunocompetent adults, in contrast to children, do not typic...
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ftdoajarticles:oai:doaj.org/article:f5b186e643ef4ec7a8e8c5001ba1a445 2023-05-15T16:13:52+02:00 Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. Eli B Nix Joshua Choi Christina Anthes Gabrielle N Gaultier Joelle Thorgrimson Andrew D Cox Raymond S W Tsang William G McCready Douglas Boreham Marina Ulanova 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0201282 https://doaj.org/article/f5b186e643ef4ec7a8e8c5001ba1a445 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6093645?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0201282 https://doaj.org/article/f5b186e643ef4ec7a8e8c5001ba1a445 PLoS ONE, Vol 13, Iss 8, p e0201282 (2018) Medicine R Science Q article 2018 ftdoajarticles https://doi.org/10.1371/journal.pone.0201282 2022-12-31T01:30:59Z During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the highest rates reported in young children. Immunocompetent adults, in contrast to children, do not typically develop invasive Hia disease. To clarify factors responsible for an increased burden of invasive Hia disease in certain population groups we studied serum bactericidal activity (SBA) against Hia and quantified IgG and IgM specific to Hia capsular polysaccharide in healthy adult members of two First Nations communities: 1) with reported cases of invasive Hia disease (Northern Ontario, NO), and 2) without reported cases (Southern Ontario, SO), in comparison to non-First Nations living in proximity to the NO First Nations community, and non-First Nations elderly non-frail Canadians from across the country (total of 110 First Nations and 76 non-First Nations). To elucidate the specificity of bactericidal antibodies, sera were absorbed with various Hia antigens. Naturally acquired SBA against Hia was detected at higher rates in First Nations (NO, 80%; SO, 96%) than non-First Nations elderly Canadians (64%); the SBA titres in First Nations were higher than in non-First Nations elderly Canadians (P<0.001) and NO non-First Nations adults (P>0.05). Among First Nations, SBA was mediated predominantly by IgM, and by both antibodies specific to Hia capsular polysaccharide and lipooligosaccharide. CONCLUSIONS:The SBA against Hia is frequently present in sera of First Nations adults regardless of the burden of Hia disease observed in their community; it may represent part of the natural antibody repertoire, which is potentially formed in this population under the influence of certain epigenetic factors. Although the nature of these antibodies deserves further studies to understand their origin, the data suggest that they may represent important protective mechanism against invasive Hia disease. Article in Journal/Newspaper First Nations inuit Directory of Open Access Journals: DOAJ Articles PLOS ONE 13 8 e0201282 |
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English |
topic |
Medicine R Science Q |
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Medicine R Science Q Eli B Nix Joshua Choi Christina Anthes Gabrielle N Gaultier Joelle Thorgrimson Andrew D Cox Raymond S W Tsang William G McCready Douglas Boreham Marina Ulanova Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
topic_facet |
Medicine R Science Q |
description |
During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the highest rates reported in young children. Immunocompetent adults, in contrast to children, do not typically develop invasive Hia disease. To clarify factors responsible for an increased burden of invasive Hia disease in certain population groups we studied serum bactericidal activity (SBA) against Hia and quantified IgG and IgM specific to Hia capsular polysaccharide in healthy adult members of two First Nations communities: 1) with reported cases of invasive Hia disease (Northern Ontario, NO), and 2) without reported cases (Southern Ontario, SO), in comparison to non-First Nations living in proximity to the NO First Nations community, and non-First Nations elderly non-frail Canadians from across the country (total of 110 First Nations and 76 non-First Nations). To elucidate the specificity of bactericidal antibodies, sera were absorbed with various Hia antigens. Naturally acquired SBA against Hia was detected at higher rates in First Nations (NO, 80%; SO, 96%) than non-First Nations elderly Canadians (64%); the SBA titres in First Nations were higher than in non-First Nations elderly Canadians (P<0.001) and NO non-First Nations adults (P>0.05). Among First Nations, SBA was mediated predominantly by IgM, and by both antibodies specific to Hia capsular polysaccharide and lipooligosaccharide. CONCLUSIONS:The SBA against Hia is frequently present in sera of First Nations adults regardless of the burden of Hia disease observed in their community; it may represent part of the natural antibody repertoire, which is potentially formed in this population under the influence of certain epigenetic factors. Although the nature of these antibodies deserves further studies to understand their origin, the data suggest that they may represent important protective mechanism against invasive Hia disease. |
format |
Article in Journal/Newspaper |
author |
Eli B Nix Joshua Choi Christina Anthes Gabrielle N Gaultier Joelle Thorgrimson Andrew D Cox Raymond S W Tsang William G McCready Douglas Boreham Marina Ulanova |
author_facet |
Eli B Nix Joshua Choi Christina Anthes Gabrielle N Gaultier Joelle Thorgrimson Andrew D Cox Raymond S W Tsang William G McCready Douglas Boreham Marina Ulanova |
author_sort |
Eli B Nix |
title |
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
title_short |
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
title_full |
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
title_fullStr |
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
title_full_unstemmed |
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study. |
title_sort |
characterization of natural bactericidal antibody against haemophilus influenzae type a in canadian first nations: a canadian immunization research network (cirn) clinical trials network (ctn) study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pone.0201282 https://doaj.org/article/f5b186e643ef4ec7a8e8c5001ba1a445 |
genre |
First Nations inuit |
genre_facet |
First Nations inuit |
op_source |
PLoS ONE, Vol 13, Iss 8, p e0201282 (2018) |
op_relation |
http://europepmc.org/articles/PMC6093645?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0201282 https://doaj.org/article/f5b186e643ef4ec7a8e8c5001ba1a445 |
op_doi |
https://doi.org/10.1371/journal.pone.0201282 |
container_title |
PLOS ONE |
container_volume |
13 |
container_issue |
8 |
container_start_page |
e0201282 |
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