Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity
It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests usin...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1991
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ftdoajarticles:oai:doaj.org/article:f582d850b6984ec4af556ad2c331a607 2023-05-15T15:13:27+02:00 Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity Maria Imaculada Muniz-Junqueira José Tavares-Neto Meire Ataide Aluizio Prata Carlos Eduardo Tosta 1991-06-01T00:00:00Z https://doaj.org/article/f582d850b6984ec4af556ad2c331a607 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/f582d850b6984ec4af556ad2c331a607 Revista da Sociedade Brasileira de Medicina Tropical, Vol 24, Iss 2, Pp 97-99 (1991) Imunodepressão Esquistossomose Oxamniquine Immunodepression Schistosomiasis Arctic medicine. Tropical medicine RC955-962 article 1991 ftdoajarticles 2022-12-30T23:08:11Z It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment Tem sido observado que infecção por Schistosoma mansoni pode causar imunodepressão celular. Neste trabalho foi avaliado se a imunodepressão associada à esquistossomose pode ser revertida pelo tratamento especifico. A resposta imune celular foi determinada através de testes cutâneos de hipersensibilidade retardada em 22 pacientes com a forma hepatoesplênica da esquistossomose um ano após tratamento com oxamniquine e comparado com aquela observada em um grupo de pacientes hepatoesplênicos não tratados. Somente 27% destes pacientes apresentaram alergia a todos os antígenos testados, em contraste com 80% de indivíduos anêrgicos observados entre aqueles não tratados. Embora a maioria dos indivíduos tratados tenha mostrado algum grau de resposta aos antígenos testados, alguns indivíduos permaneceram anérgicos após o tratamento específico. Anergia a todos os antígenos aplicados não foi observada em nenhum dos indivíduos normais. Nossos dados indicam que pacientes esquistossomóticos podem recuperar ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Imunodepressão Esquistossomose Oxamniquine Immunodepression Schistosomiasis Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Imunodepressão Esquistossomose Oxamniquine Immunodepression Schistosomiasis Arctic medicine. Tropical medicine RC955-962 Maria Imaculada Muniz-Junqueira José Tavares-Neto Meire Ataide Aluizio Prata Carlos Eduardo Tosta Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
topic_facet |
Imunodepressão Esquistossomose Oxamniquine Immunodepression Schistosomiasis Arctic medicine. Tropical medicine RC955-962 |
description |
It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. T-cell immune response was assessed by means of intradermal tests using recall antigens in a group of 22 patients with hepatosplenic schistosomiasis, one year after treatment with oxamniquine and compared with a group of untreated hepatosplenic patients. Only 27% of treated patients presented complete anergy to all tested antigens, in marked contrast to 80% unresponsiveness showed by hepatosplenic patients without treatment. Although most of the treated individuals showed some response to the tested antigens, in some individuals this unresponsiveness still persisted after treatment. Anergy was not found in any normal individual of the control group. It was concluded that Schistosoma mansoni infected patients may recover their normal immune responsiveness after the elimination of the worm by treatment Tem sido observado que infecção por Schistosoma mansoni pode causar imunodepressão celular. Neste trabalho foi avaliado se a imunodepressão associada à esquistossomose pode ser revertida pelo tratamento especifico. A resposta imune celular foi determinada através de testes cutâneos de hipersensibilidade retardada em 22 pacientes com a forma hepatoesplênica da esquistossomose um ano após tratamento com oxamniquine e comparado com aquela observada em um grupo de pacientes hepatoesplênicos não tratados. Somente 27% destes pacientes apresentaram alergia a todos os antígenos testados, em contraste com 80% de indivíduos anêrgicos observados entre aqueles não tratados. Embora a maioria dos indivíduos tratados tenha mostrado algum grau de resposta aos antígenos testados, alguns indivíduos permaneceram anérgicos após o tratamento específico. Anergia a todos os antígenos aplicados não foi observada em nenhum dos indivíduos normais. Nossos dados indicam que pacientes esquistossomóticos podem recuperar ... |
format |
Article in Journal/Newspaper |
author |
Maria Imaculada Muniz-Junqueira José Tavares-Neto Meire Ataide Aluizio Prata Carlos Eduardo Tosta |
author_facet |
Maria Imaculada Muniz-Junqueira José Tavares-Neto Meire Ataide Aluizio Prata Carlos Eduardo Tosta |
author_sort |
Maria Imaculada Muniz-Junqueira |
title |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_short |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_full |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_fullStr |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_full_unstemmed |
Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity |
title_sort |
specific treatment of hepatosplenic schistosomiasis can increase t-lymphocyte reactivity |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1991 |
url |
https://doaj.org/article/f582d850b6984ec4af556ad2c331a607 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 24, Iss 2, Pp 97-99 (1991) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821991000200005 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/f582d850b6984ec4af556ad2c331a607 |
_version_ |
1766344004575690752 |