Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Fernanda Fortes de Araujo, Rana Nagarkatti, Charu Gupta, Ana Paula Marino, Alain Debrabant
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2015
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Ela
• Online Access: https://doi.org/10.1371/journal.pntd.0003451; https://doaj.org/article/f531793561e24b30b3ae998a996b8232

Drug discovery initiatives, aimed at Chagas treatment, have been hampered by the lack of standardized drug screening protocols and the absence of simple pre-clinical assays to evaluate treatment efficacy in animal models. In this study, we used a simple Enzyme Linked Aptamer (ELA) assay to detect T....