Single visit rabies pre-exposure prophylaxis: A literature review
Background: The current WHO-recommended rabies pre-exposure prophylaxis (PrEP) are two-visit vaccination schedules, but there are studies suggesting that single visit schedules might be sufficient to prime the immunity. Methods: A literature review was conducted to retrieve and summarize published d...
Published in: | Travel Medicine and Infectious Disease |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.tmaid.2023.102612 https://doaj.org/article/f503c6616d274edca3cfa78c7fcfa70e |
id |
ftdoajarticles:oai:doaj.org/article:f503c6616d274edca3cfa78c7fcfa70e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f503c6616d274edca3cfa78c7fcfa70e 2023-09-05T13:17:38+02:00 Single visit rabies pre-exposure prophylaxis: A literature review Benjamin Damanet Diana Isabela Costescu Strachinaru Alain Levêque 2023-07-01T00:00:00Z https://doi.org/10.1016/j.tmaid.2023.102612 https://doaj.org/article/f503c6616d274edca3cfa78c7fcfa70e EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1477893923000728 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102612 https://doaj.org/article/f503c6616d274edca3cfa78c7fcfa70e Travel Medicine and Infectious Disease, Vol 54, Iss , Pp 102612- (2023) Rabies Pre-exposure Single visit Vaccines Vaccination schedule Review Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1016/j.tmaid.2023.102612 2023-08-13T00:36:03Z Background: The current WHO-recommended rabies pre-exposure prophylaxis (PrEP) are two-visit vaccination schedules, but there are studies suggesting that single visit schedules might be sufficient to prime the immunity. Methods: A literature review was conducted to retrieve and summarize published data on single visit rabies PrEP. PubMed database was screened for articles published between January 1st, 2003 and December 31st, 2022. The bibliographies of the articles chosen to undergo full text review and of the current major WHO publications on rabies were searched to find additional references, regardless of publication date. The primary outcome was the percentage of subjects having received rabies PrEP on single visit schedules who achieved antibody levels ≥0.5 IU/mL one week after post-exposure prophylaxis (PEP), regardless of the PEP regimen. Results: 11 studies were selected for inclusion, totalling 935 subjects, of which 696 received a simulated PEP schedule. Of these 696, a serological test result on day 7 was available for 408 of them, and 406 subjects (99.51%) seroconverted after PEP without any difference regarding time delay between PrEP and PEP or the vaccination schedule used for PEP. Conclusion: Single visit PrEP schedules seem to confer sufficient protection in most healthy individuals without immunocompromised status if a booster PEP is administered after a suspected rabies exposure. Further studies in real-life settings and in different age categories are needed to confirm this finding, which may increase the availability of vaccines and thus the accessibility of PrEP for vulnerable populations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Travel Medicine and Infectious Disease 54 102612 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Rabies Pre-exposure Single visit Vaccines Vaccination schedule Review Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Rabies Pre-exposure Single visit Vaccines Vaccination schedule Review Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Benjamin Damanet Diana Isabela Costescu Strachinaru Alain Levêque Single visit rabies pre-exposure prophylaxis: A literature review |
topic_facet |
Rabies Pre-exposure Single visit Vaccines Vaccination schedule Review Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Background: The current WHO-recommended rabies pre-exposure prophylaxis (PrEP) are two-visit vaccination schedules, but there are studies suggesting that single visit schedules might be sufficient to prime the immunity. Methods: A literature review was conducted to retrieve and summarize published data on single visit rabies PrEP. PubMed database was screened for articles published between January 1st, 2003 and December 31st, 2022. The bibliographies of the articles chosen to undergo full text review and of the current major WHO publications on rabies were searched to find additional references, regardless of publication date. The primary outcome was the percentage of subjects having received rabies PrEP on single visit schedules who achieved antibody levels ≥0.5 IU/mL one week after post-exposure prophylaxis (PEP), regardless of the PEP regimen. Results: 11 studies were selected for inclusion, totalling 935 subjects, of which 696 received a simulated PEP schedule. Of these 696, a serological test result on day 7 was available for 408 of them, and 406 subjects (99.51%) seroconverted after PEP without any difference regarding time delay between PrEP and PEP or the vaccination schedule used for PEP. Conclusion: Single visit PrEP schedules seem to confer sufficient protection in most healthy individuals without immunocompromised status if a booster PEP is administered after a suspected rabies exposure. Further studies in real-life settings and in different age categories are needed to confirm this finding, which may increase the availability of vaccines and thus the accessibility of PrEP for vulnerable populations. |
format |
Article in Journal/Newspaper |
author |
Benjamin Damanet Diana Isabela Costescu Strachinaru Alain Levêque |
author_facet |
Benjamin Damanet Diana Isabela Costescu Strachinaru Alain Levêque |
author_sort |
Benjamin Damanet |
title |
Single visit rabies pre-exposure prophylaxis: A literature review |
title_short |
Single visit rabies pre-exposure prophylaxis: A literature review |
title_full |
Single visit rabies pre-exposure prophylaxis: A literature review |
title_fullStr |
Single visit rabies pre-exposure prophylaxis: A literature review |
title_full_unstemmed |
Single visit rabies pre-exposure prophylaxis: A literature review |
title_sort |
single visit rabies pre-exposure prophylaxis: a literature review |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.tmaid.2023.102612 https://doaj.org/article/f503c6616d274edca3cfa78c7fcfa70e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Travel Medicine and Infectious Disease, Vol 54, Iss , Pp 102612- (2023) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1477893923000728 https://doaj.org/toc/1873-0442 1873-0442 doi:10.1016/j.tmaid.2023.102612 https://doaj.org/article/f503c6616d274edca3cfa78c7fcfa70e |
op_doi |
https://doi.org/10.1016/j.tmaid.2023.102612 |
container_title |
Travel Medicine and Infectious Disease |
container_volume |
54 |
container_start_page |
102612 |
_version_ |
1776198731607048192 |