Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses.
Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface.We measured MAIT cell frequencies and antibody responses in blood from patients presenting with culture-confirmed...
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ftdoajarticles:oai:doaj.org/article:f5024363c82b4ed889f1eda6a2aaf9bf 2023-05-15T15:06:27+02:00 Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. Daniel T Leung Taufiqur R Bhuiyan Naoshin S Nishat Mohammad Rubel Hoq Amena Aktar M Arifur Rahman Taher Uddin Ashraful I Khan Fahima Chowdhury Richelle C Charles Jason B Harris Stephen B Calderwood Firdausi Qadri Edward T Ryan 2014-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003076 https://doaj.org/article/f5024363c82b4ed889f1eda6a2aaf9bf EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4140671?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003076 https://doaj.org/article/f5024363c82b4ed889f1eda6a2aaf9bf PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3076 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003076 2022-12-31T13:43:46Z Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface.We measured MAIT cell frequencies and antibody responses in blood from patients presenting with culture-confirmed severe cholera to a hospital in Dhaka, Bangladesh at days 2, 7, 30, and 90 of illness.We found that MAIT (CD3+CD4-CD161hiVĪ±7.2+) cells were maximally activated at day 7 after onset of cholera. In adult patients, MAIT frequencies did not change over time, whereas in child patients, MAITs were significantly decreased at day 7, and this decrease persisted to day 90. Fold changes in MAIT frequency correlated with increases in LPS IgA and IgG, but not LPS IgM nor antibody responses to cholera toxin B subunit.In the acute phase of cholera, MAIT cells are activated, depleted from the periphery, and as part of the innate response against V. cholerae infection, are possibly involved in mechanisms underlying class switching of antibody responses to T cell-independent antigens. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 8 e3076 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Daniel T Leung Taufiqur R Bhuiyan Naoshin S Nishat Mohammad Rubel Hoq Amena Aktar M Arifur Rahman Taher Uddin Ashraful I Khan Fahima Chowdhury Richelle C Charles Jason B Harris Stephen B Calderwood Firdausi Qadri Edward T Ryan Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface.We measured MAIT cell frequencies and antibody responses in blood from patients presenting with culture-confirmed severe cholera to a hospital in Dhaka, Bangladesh at days 2, 7, 30, and 90 of illness.We found that MAIT (CD3+CD4-CD161hiVĪ±7.2+) cells were maximally activated at day 7 after onset of cholera. In adult patients, MAIT frequencies did not change over time, whereas in child patients, MAITs were significantly decreased at day 7, and this decrease persisted to day 90. Fold changes in MAIT frequency correlated with increases in LPS IgA and IgG, but not LPS IgM nor antibody responses to cholera toxin B subunit.In the acute phase of cholera, MAIT cells are activated, depleted from the periphery, and as part of the innate response against V. cholerae infection, are possibly involved in mechanisms underlying class switching of antibody responses to T cell-independent antigens. |
format |
Article in Journal/Newspaper |
author |
Daniel T Leung Taufiqur R Bhuiyan Naoshin S Nishat Mohammad Rubel Hoq Amena Aktar M Arifur Rahman Taher Uddin Ashraful I Khan Fahima Chowdhury Richelle C Charles Jason B Harris Stephen B Calderwood Firdausi Qadri Edward T Ryan |
author_facet |
Daniel T Leung Taufiqur R Bhuiyan Naoshin S Nishat Mohammad Rubel Hoq Amena Aktar M Arifur Rahman Taher Uddin Ashraful I Khan Fahima Chowdhury Richelle C Charles Jason B Harris Stephen B Calderwood Firdausi Qadri Edward T Ryan |
author_sort |
Daniel T Leung |
title |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
title_short |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
title_full |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
title_fullStr |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
title_full_unstemmed |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. |
title_sort |
circulating mucosal associated invariant t cells are activated in vibrio cholerae o1 infection and associated with lipopolysaccharide antibody responses. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003076 https://doaj.org/article/f5024363c82b4ed889f1eda6a2aaf9bf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3076 (2014) |
op_relation |
http://europepmc.org/articles/PMC4140671?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003076 https://doaj.org/article/f5024363c82b4ed889f1eda6a2aaf9bf |
op_doi |
https://doi.org/10.1371/journal.pntd.0003076 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
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8 |
container_start_page |
e3076 |
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