A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
BACKGROUND: Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable...
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ftdoajarticles:oai:doaj.org/article:f49394c9162b43378efa459d77a32285 2023-05-15T15:07:47+02:00 A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. Veerle Lejon Dieudonné Mumba Ngoyi Marleen Boelaert Philippe Büscher 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000590 https://doaj.org/article/f49394c9162b43378efa459d77a32285 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2811173?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0000590 1935-2727 1935-2735 https://doaj.org/article/f49394c9162b43378efa459d77a32285 PLoS Neglected Tropical Diseases, Vol 4, Iss 1, p e590 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000590 2022-12-31T11:46:23Z BACKGROUND: Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card Agglutination Test for Trypanosomiasis (CATT). We studied the value of a normalising, negative post-treatment CATT result in treated Trypanosoma brucei (T.b.) gambiense sleeping sickness patients as a marker of cure. METHODOLOGY/PRINCIPAL FINDINGS: The CATT/T.b. gambiense was performed on serum of a cohort of 360 T.b. gambiense patients, consisting of 242 primary and 118 retreatment cases. The CATT results during 2 years of post-treatment follow-up were studied in function of cure or treatment failure. At inclusion, sensitivity of CATT was 98% (234/238) in primary cases and only 78% (91/117) in retreatment cases. After treatment, the CATT titre decreased both in cured patients and in patients experiencing treatment failure. CONCLUSIONS/SIGNIFICANCE: Though CATT is a good test to detect HAT in primary cases, a normalising or negative CATT result after treatment for HAT does not indicate cure, therefore CATT cannot be used to monitor treatment outcome. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 1 e590 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Veerle Lejon Dieudonné Mumba Ngoyi Marleen Boelaert Philippe Büscher A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card Agglutination Test for Trypanosomiasis (CATT). We studied the value of a normalising, negative post-treatment CATT result in treated Trypanosoma brucei (T.b.) gambiense sleeping sickness patients as a marker of cure. METHODOLOGY/PRINCIPAL FINDINGS: The CATT/T.b. gambiense was performed on serum of a cohort of 360 T.b. gambiense patients, consisting of 242 primary and 118 retreatment cases. The CATT results during 2 years of post-treatment follow-up were studied in function of cure or treatment failure. At inclusion, sensitivity of CATT was 98% (234/238) in primary cases and only 78% (91/117) in retreatment cases. After treatment, the CATT titre decreased both in cured patients and in patients experiencing treatment failure. CONCLUSIONS/SIGNIFICANCE: Though CATT is a good test to detect HAT in primary cases, a normalising or negative CATT result after treatment for HAT does not indicate cure, therefore CATT cannot be used to monitor treatment outcome. |
format |
Article in Journal/Newspaper |
author |
Veerle Lejon Dieudonné Mumba Ngoyi Marleen Boelaert Philippe Büscher |
author_facet |
Veerle Lejon Dieudonné Mumba Ngoyi Marleen Boelaert Philippe Büscher |
author_sort |
Veerle Lejon |
title |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
title_short |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
title_full |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
title_fullStr |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
title_full_unstemmed |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. |
title_sort |
catt negative result after treatment for human african trypanosomiasis is no indication for cure. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000590 https://doaj.org/article/f49394c9162b43378efa459d77a32285 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 1, p e590 (2010) |
op_relation |
http://europepmc.org/articles/PMC2811173?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0000590 1935-2727 1935-2735 https://doaj.org/article/f49394c9162b43378efa459d77a32285 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000590 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
4 |
container_issue |
1 |
container_start_page |
e590 |
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1766339216589979648 |