Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials
The objective of this meta-analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th...
Published in: | Journal of Tropical Medicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1155/2022/4857872 https://doaj.org/article/f44840c5af3b448081c23d0fb7d5a23b |
id |
ftdoajarticles:oai:doaj.org/article:f44840c5af3b448081c23d0fb7d5a23b |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f44840c5af3b448081c23d0fb7d5a23b 2024-09-09T19:26:12+00:00 Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials Aidibai Simayi Liguo Zhu Hui Jin 2022-01-01T00:00:00Z https://doi.org/10.1155/2022/4857872 https://doaj.org/article/f44840c5af3b448081c23d0fb7d5a23b EN eng Wiley http://dx.doi.org/10.1155/2022/4857872 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4857872 https://doaj.org/article/f44840c5af3b448081c23d0fb7d5a23b Journal of Tropical Medicine, Vol 2022 (2022) Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1155/2022/4857872 2024-08-05T17:48:36Z The objective of this meta-analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th of October 2021, using a protocol registered on PROSPERO with no. 42021287717, and a meta-analysis was conducted. We measured pooled geometric mean concentrations (GMCs) for IgG antibodies against pertussis and the incidence of serious adverse events (SAEs). We identified a total of 522 publications, and after a strict screening, we found that 6 RCTs were eligible for our meta-analysis. GMCs were determined with a standardized mean difference (SMD), and the pooled SMD of anti-PT, anti-FHA, and anti-PRN IgG from cord blood were 0.91 (95% CI: 0.58, 1.24), 1.03 (95% CI: (0.70, 1.35)), and 1.55(95% CI: 1.22, 1.88), respectively. The pooled OR of SAEs of women and infants did not show a statistical difference; the pooled ORs were 1.26 (95% CI: 0.78, 2.05); P=0.35) and 0.61 (95% CI: 0.37, 1.01); p=0.053), respectively. Infants of immunized women have significantly higher transplacental antibodies for protection against pertussis disease during the first 2 months of life. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Fang ENVELOPE(167.217,167.217,-77.483,-77.483) Journal of Tropical Medicine 2022 1 8 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Aidibai Simayi Liguo Zhu Hui Jin Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The objective of this meta-analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th of October 2021, using a protocol registered on PROSPERO with no. 42021287717, and a meta-analysis was conducted. We measured pooled geometric mean concentrations (GMCs) for IgG antibodies against pertussis and the incidence of serious adverse events (SAEs). We identified a total of 522 publications, and after a strict screening, we found that 6 RCTs were eligible for our meta-analysis. GMCs were determined with a standardized mean difference (SMD), and the pooled SMD of anti-PT, anti-FHA, and anti-PRN IgG from cord blood were 0.91 (95% CI: 0.58, 1.24), 1.03 (95% CI: (0.70, 1.35)), and 1.55(95% CI: 1.22, 1.88), respectively. The pooled OR of SAEs of women and infants did not show a statistical difference; the pooled ORs were 1.26 (95% CI: 0.78, 2.05); P=0.35) and 0.61 (95% CI: 0.37, 1.01); p=0.053), respectively. Infants of immunized women have significantly higher transplacental antibodies for protection against pertussis disease during the first 2 months of life. |
format |
Article in Journal/Newspaper |
author |
Aidibai Simayi Liguo Zhu Hui Jin |
author_facet |
Aidibai Simayi Liguo Zhu Hui Jin |
author_sort |
Aidibai Simayi |
title |
Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
title_short |
Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
title_full |
Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
title_fullStr |
Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
title_full_unstemmed |
Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta-Analysis of Randomized Clinical Trials |
title_sort |
safety and immunogenicity of pertussis vaccine immunization during pregnancy: a meta-analysis of randomized clinical trials |
publisher |
Wiley |
publishDate |
2022 |
url |
https://doi.org/10.1155/2022/4857872 https://doaj.org/article/f44840c5af3b448081c23d0fb7d5a23b |
long_lat |
ENVELOPE(167.217,167.217,-77.483,-77.483) |
geographic |
Arctic Fang |
geographic_facet |
Arctic Fang |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2022 (2022) |
op_relation |
http://dx.doi.org/10.1155/2022/4857872 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4857872 https://doaj.org/article/f44840c5af3b448081c23d0fb7d5a23b |
op_doi |
https://doi.org/10.1155/2022/4857872 |
container_title |
Journal of Tropical Medicine |
container_volume |
2022 |
container_start_page |
1 |
op_container_end_page |
8 |
_version_ |
1809895863025139712 |