Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Danielle Thompson, Ben Guenther, Darly Manayani, Jason Mendy, Jonathan Smith, Diego A Espinosa, Eva Harris, Jeff Alexander, Lo Vang, Christopher S Morello
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2022
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Barré
• Online Access: https://doi.org/10.1371/journal.pntd.0010588; https://doaj.org/article/f3fe48d30d62421cb530592af7854bb0

Zika virus (ZIKV) is a mosquito-borne flavivirus with maternal infection associated with preterm birth, congenital malformations, and fetal death, and adult infection associated with Guillain-Barré syndrome. Recent widespread endemic transmission of ZIKV and the potential for future outbreaks necess...