Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya.
BACKGROUND:The implementation of soil-transmitted helminth (STH) treatment programmes occurs in varied environmental, social and economic contexts. Programme impact will be influenced by factors that affect the reduction in the prevalence and intensity of infections following treatment, as well as t...
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ftdoajarticles:oai:doaj.org/article:f3e6ca77361648ac88fba48d8ff34773 2023-05-15T15:12:34+02:00 Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. Birgit Nikolay Charles S Mwandawiro Jimmy H Kihara Collins Okoyo Jorge Cano Mariam T Mwanje Hadley Sultani Dorcas Alusala Hugo C Turner Caroline Teti Josh Garn Matthew C Freeman Elizabeth Allen Roy M Anderson Rachel L Pullan Sammy M Njenga Simon J Brooker 2015-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004108 https://doaj.org/article/f3e6ca77361648ac88fba48d8ff34773 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4589351?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004108 https://doaj.org/article/f3e6ca77361648ac88fba48d8ff34773 PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004108 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004108 2022-12-30T21:54:50Z BACKGROUND:The implementation of soil-transmitted helminth (STH) treatment programmes occurs in varied environmental, social and economic contexts. Programme impact will be influenced by factors that affect the reduction in the prevalence and intensity of infections following treatment, as well as the subsequent rate of reinfection. To better understand the heterogeneity of programme impact and its underlying reasons, we investigated the influence of contextual factors on reduction in STH infection as part of the national school based deworming (SBD) programme in Kenya. MATERIALS AND METHODS:Data on the prevalence and intensity of infection were collected within the monitoring and evaluation component of the SBD programme at baseline and after delivery of two annual treatment rounds in 153 schools in western Kenya. Using a framework that considers STH epidemiology and transmission dynamics, capacity to deliver treatment, operational feasibility and financial capacity, data were assembled at both school and district (county) levels. Geographic heterogeneity of programme impact was assessed by descriptive and spatial analyses. Factors associated with absolute reductions of Ascaris lumbricoides and hookworm infection prevalence and intensity were identified using mixed effects linear regression modelling adjusting for baseline infection levels. PRINCIPAL FINDINGS:The reduction in prevalence and intensity of A. lumbricoides and hookworms varied significantly by county and within counties by school. Multivariable analysis of factors associated with programme impact showed that absolute A. lumbricoides reductions varied by environmental conditions and access to improved sanitation at schools or within the community. Larger reduction in prevalence and intensity of hookworms were found in schools located within areas with higher community level access to improved sanitation and within counties with higher economic and health service delivery indicator scores. CONCLUSIONS:The study identifies factors associated with the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 9 e0004108 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Birgit Nikolay Charles S Mwandawiro Jimmy H Kihara Collins Okoyo Jorge Cano Mariam T Mwanje Hadley Sultani Dorcas Alusala Hugo C Turner Caroline Teti Josh Garn Matthew C Freeman Elizabeth Allen Roy M Anderson Rachel L Pullan Sammy M Njenga Simon J Brooker Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The implementation of soil-transmitted helminth (STH) treatment programmes occurs in varied environmental, social and economic contexts. Programme impact will be influenced by factors that affect the reduction in the prevalence and intensity of infections following treatment, as well as the subsequent rate of reinfection. To better understand the heterogeneity of programme impact and its underlying reasons, we investigated the influence of contextual factors on reduction in STH infection as part of the national school based deworming (SBD) programme in Kenya. MATERIALS AND METHODS:Data on the prevalence and intensity of infection were collected within the monitoring and evaluation component of the SBD programme at baseline and after delivery of two annual treatment rounds in 153 schools in western Kenya. Using a framework that considers STH epidemiology and transmission dynamics, capacity to deliver treatment, operational feasibility and financial capacity, data were assembled at both school and district (county) levels. Geographic heterogeneity of programme impact was assessed by descriptive and spatial analyses. Factors associated with absolute reductions of Ascaris lumbricoides and hookworm infection prevalence and intensity were identified using mixed effects linear regression modelling adjusting for baseline infection levels. PRINCIPAL FINDINGS:The reduction in prevalence and intensity of A. lumbricoides and hookworms varied significantly by county and within counties by school. Multivariable analysis of factors associated with programme impact showed that absolute A. lumbricoides reductions varied by environmental conditions and access to improved sanitation at schools or within the community. Larger reduction in prevalence and intensity of hookworms were found in schools located within areas with higher community level access to improved sanitation and within counties with higher economic and health service delivery indicator scores. CONCLUSIONS:The study identifies factors associated with the ... |
format |
Article in Journal/Newspaper |
author |
Birgit Nikolay Charles S Mwandawiro Jimmy H Kihara Collins Okoyo Jorge Cano Mariam T Mwanje Hadley Sultani Dorcas Alusala Hugo C Turner Caroline Teti Josh Garn Matthew C Freeman Elizabeth Allen Roy M Anderson Rachel L Pullan Sammy M Njenga Simon J Brooker |
author_facet |
Birgit Nikolay Charles S Mwandawiro Jimmy H Kihara Collins Okoyo Jorge Cano Mariam T Mwanje Hadley Sultani Dorcas Alusala Hugo C Turner Caroline Teti Josh Garn Matthew C Freeman Elizabeth Allen Roy M Anderson Rachel L Pullan Sammy M Njenga Simon J Brooker |
author_sort |
Birgit Nikolay |
title |
Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
title_short |
Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
title_full |
Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
title_fullStr |
Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
title_full_unstemmed |
Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. |
title_sort |
understanding heterogeneity in the impact of national neglected tropical disease control programmes: evidence from school-based deworming in kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0004108 https://doaj.org/article/f3e6ca77361648ac88fba48d8ff34773 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004108 (2015) |
op_relation |
http://europepmc.org/articles/PMC4589351?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004108 https://doaj.org/article/f3e6ca77361648ac88fba48d8ff34773 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004108 |
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PLOS Neglected Tropical Diseases |
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9 |
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e0004108 |
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