FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES
The medical records of patients with AIDS admitted to a general hospital in Brazil from 1989 to 1997 were reviewed retrospectively with the aim at defining the frequency and etiology of fever of undetermined origin (FUO) in HIV-infected patients of a tropical country and to evaluate the usefulness o...
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ftdoajarticles:oai:doaj.org/article:f35acf051c204f73af121f66ef2c897b 2024-09-09T19:26:56+00:00 FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES J. Roberto LAMBERTUCCI Abdunnabi A.M. RAYES Frank NUNES Jairo Enrique LANDAZURI-PALACIOS Vandack NOBRE 1999-01-01T00:00:00Z https://doaj.org/article/f35acf051c204f73af121f66ef2c897b EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000100006&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/f35acf051c204f73af121f66ef2c897b Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 1, Pp 27-32 (1999) Fever Fever of unknown origin AIDS Acquired immunodeficiency syndrome Fever of undetermined origin Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1999 ftdoajarticles 2024-08-05T17:49:30Z The medical records of patients with AIDS admitted to a general hospital in Brazil from 1989 to 1997 were reviewed retrospectively with the aim at defining the frequency and etiology of fever of undetermined origin (FUO) in HIV-infected patients of a tropical country and to evaluate the usefulness of the main diagnostic procedures. 188 (58.4%) out of 322 patients reported fever at admission to hospital and 55 (17.1%) had FUO. Those with FUO had a mean CD4+ cell count of 98/ml. A cause of fever was identified for 45 patients (81.8%). Tuberculosis (32.7%), Pneumocystis carinii pneumonia (10.9%), and Mycobacterium avium complex (9.1%) were the most frequent diagnoses. Other infectious diseases are also of note, such as cryptococcal meningitis (5.5%), sinusitis (3.6%), Salmonella-S. mansoni association (3.6%), disseminated histoplasmosis (3.6%), neurosyphilis (1.8%), and isosporiasis (1.8%). Four patients had non-Hodgkin's lymphoma (7.3%). We conclude that an initial aggressive diagnostic approach should be always considered because biopsies (lymph node, liver and bone marrow) produced the highest yield in the diagnosis of FUO and the majority of the diagnosed diseases are treatable. The association of diseases is common and have contributed to delay the final diagnosis of FUO in most cases. In our study area the routine request of hemocultures for Salmonella infection and the investigation of cryptococcal antigen in the serum should be considered. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Fever Fever of unknown origin AIDS Acquired immunodeficiency syndrome Fever of undetermined origin Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Fever Fever of unknown origin AIDS Acquired immunodeficiency syndrome Fever of undetermined origin Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 J. Roberto LAMBERTUCCI Abdunnabi A.M. RAYES Frank NUNES Jairo Enrique LANDAZURI-PALACIOS Vandack NOBRE FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
topic_facet |
Fever Fever of unknown origin AIDS Acquired immunodeficiency syndrome Fever of undetermined origin Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The medical records of patients with AIDS admitted to a general hospital in Brazil from 1989 to 1997 were reviewed retrospectively with the aim at defining the frequency and etiology of fever of undetermined origin (FUO) in HIV-infected patients of a tropical country and to evaluate the usefulness of the main diagnostic procedures. 188 (58.4%) out of 322 patients reported fever at admission to hospital and 55 (17.1%) had FUO. Those with FUO had a mean CD4+ cell count of 98/ml. A cause of fever was identified for 45 patients (81.8%). Tuberculosis (32.7%), Pneumocystis carinii pneumonia (10.9%), and Mycobacterium avium complex (9.1%) were the most frequent diagnoses. Other infectious diseases are also of note, such as cryptococcal meningitis (5.5%), sinusitis (3.6%), Salmonella-S. mansoni association (3.6%), disseminated histoplasmosis (3.6%), neurosyphilis (1.8%), and isosporiasis (1.8%). Four patients had non-Hodgkin's lymphoma (7.3%). We conclude that an initial aggressive diagnostic approach should be always considered because biopsies (lymph node, liver and bone marrow) produced the highest yield in the diagnosis of FUO and the majority of the diagnosed diseases are treatable. The association of diseases is common and have contributed to delay the final diagnosis of FUO in most cases. In our study area the routine request of hemocultures for Salmonella infection and the investigation of cryptococcal antigen in the serum should be considered. |
format |
Article in Journal/Newspaper |
author |
J. Roberto LAMBERTUCCI Abdunnabi A.M. RAYES Frank NUNES Jairo Enrique LANDAZURI-PALACIOS Vandack NOBRE |
author_facet |
J. Roberto LAMBERTUCCI Abdunnabi A.M. RAYES Frank NUNES Jairo Enrique LANDAZURI-PALACIOS Vandack NOBRE |
author_sort |
J. Roberto LAMBERTUCCI |
title |
FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
title_short |
FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
title_full |
FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
title_fullStr |
FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
title_full_unstemmed |
FEVER OF UNDETERMINED ORIGIN IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME IN BRAZIL: REPORT ON 55 CASES |
title_sort |
fever of undetermined origin in patients with the acquired immunodeficiency syndrome in brazil: report on 55 cases |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1999 |
url |
https://doaj.org/article/f35acf051c204f73af121f66ef2c897b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 1, Pp 27-32 (1999) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000100006&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/f35acf051c204f73af121f66ef2c897b |
_version_ |
1809896467665518592 |