How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?
Abstract Malaria continues to be an enormous global health challenge, with millions of new infections and deaths reported annually. This is partly due to the development of resistance by the malaria parasite to the majority of established anti-malarial drugs, a situation that continues to hamper att...
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ftdoajarticles:oai:doaj.org/article:f350060e563843e59881fc41dde199a3 2023-05-15T15:06:08+02:00 How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? Chibale Kelly Guantai Eric 2011-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-S1-S2 https://doaj.org/article/f350060e563843e59881fc41dde199a3 EN eng BMC http://www.malariajournal.com/content/10/S1/S2 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S2 1475-2875 https://doaj.org/article/f350060e563843e59881fc41dde199a3 Malaria Journal, Vol 10, Iss Suppl 1, p S2 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-S1-S2 2022-12-31T13:51:55Z Abstract Malaria continues to be an enormous global health challenge, with millions of new infections and deaths reported annually. This is partly due to the development of resistance by the malaria parasite to the majority of established anti-malarial drugs, a situation that continues to hamper attempts at controlling the disease. This has spurred intensive drug discovery endeavours geared towards identifying novel, highly active anti-malarial drugs, and the identification of quality leads from natural sources would greatly augment these efforts. The current reality is that other than compounds that have their foundation in historic natural products, there are no other compounds in drug discovery as part of lead optimization projects and preclinical development or further that have originated from a natural product start-point in recent years. This paper briefly presents both classical as well as some more modern, but underutilized, approaches that have been applied outside the field of malaria, and which could be considered in enhancing the potential of natural products to provide or inspire the development of anti-malarial lead compounds. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Start Point ENVELOPE(-61.216,-61.216,-62.589,-62.589) Malaria Journal 10 S1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Chibale Kelly Guantai Eric How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Malaria continues to be an enormous global health challenge, with millions of new infections and deaths reported annually. This is partly due to the development of resistance by the malaria parasite to the majority of established anti-malarial drugs, a situation that continues to hamper attempts at controlling the disease. This has spurred intensive drug discovery endeavours geared towards identifying novel, highly active anti-malarial drugs, and the identification of quality leads from natural sources would greatly augment these efforts. The current reality is that other than compounds that have their foundation in historic natural products, there are no other compounds in drug discovery as part of lead optimization projects and preclinical development or further that have originated from a natural product start-point in recent years. This paper briefly presents both classical as well as some more modern, but underutilized, approaches that have been applied outside the field of malaria, and which could be considered in enhancing the potential of natural products to provide or inspire the development of anti-malarial lead compounds. |
format |
Article in Journal/Newspaper |
author |
Chibale Kelly Guantai Eric |
author_facet |
Chibale Kelly Guantai Eric |
author_sort |
Chibale Kelly |
title |
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
title_short |
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
title_full |
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
title_fullStr |
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
title_full_unstemmed |
How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
title_sort |
how can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials? |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-S1-S2 https://doaj.org/article/f350060e563843e59881fc41dde199a3 |
long_lat |
ENVELOPE(-61.216,-61.216,-62.589,-62.589) |
geographic |
Arctic Start Point |
geographic_facet |
Arctic Start Point |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss Suppl 1, p S2 (2011) |
op_relation |
http://www.malariajournal.com/content/10/S1/S2 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S2 1475-2875 https://doaj.org/article/f350060e563843e59881fc41dde199a3 |
op_doi |
https://doi.org/10.1186/1475-2875-10-S1-S2 |
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Malaria Journal |
container_volume |
10 |
container_issue |
S1 |
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1766337795862822912 |