Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Jia-Li Wang, Jun-Lei Zhang, Wei Chen, Xiao-Feng Xu, Na Gao, Dong-Ying Fan, Jing An
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2010
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Rho
• Online Access: https://doi.org/10.1371/journal.pntd.0000809; https://doaj.org/article/f31d8cd2d5a04db3ab5c2985701fbce4

BACKGROUND: Increased vascular permeability is a hallmark feature in severe dengue virus (DV) infection, and dysfunction of endothelial cells has been speculated to contribute in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Rho-family GTPase Rac1 is a significant ele...